CURRICULUM VITAE
GABRIELE MISSALE
BIOGRAPHICAL INFORMATION
Name: Gabriele Missale
Date of Birth: March 9, 1963
Citizenship: Italian
Business Address: University Hospital of Parma, Via Gramsci 14, 43126 Parma, Italy
E-mail: gabriele.missale@unipr.it
EDUCATION AND TRAINING
1988 – MD, University of Parma
1994 – Board Certification in Infectious Diseases, University of Parma
2000 – Board Certification in Gastroenterology, University of Siena
2012 – National Scientific Qualification, Associate Professor
2014 – National Scientific Qualification, Full Professor
2015 – Executive Management Certification for Directors of Complex Healthcare Units
1991–1992 – Research Fellowship in Viral Immunology, The Scripps Research Institute, La Jolla, CA, USA
1993 – Research Fellowship in Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
ACADEMIC AND CLINICAL APPOINTMENTS
1992–1994 Staff Physician, Parma Local Health Authority
1994–1997 Physician, Infectious Diseases Unit, University Hospital of Parma
1997–2017 Consultant Physician, Infectious Diseases Unit, University Hospital of Parma
2001–2012 Head, Viral Immunopathology Laboratory
2016–present Coordinator of the Multidisciplinary Clinical Care Pathway for Focal Liver Lesions
2017–2023 Head, Diagnostic and Interventional Ultrasound Unit
2018–2024 Associate Professor of Infectious Diseases, University of Parma
2023–present Director, Infectious Diseases and Hepatology Unit, University Hospital of Parma
2023–present Director, Residency Program in Infectious and Tropical Diseases
2024–present Full Professor of Infectious Diseases, University of Parma
SCIENTIFIC SOCIETIES, EDITORIAL ACTIVITIES AND ETHICS
Member of AISF, SIUMB and SIMIT.
Member of the AISF Scientific Coordinating Committee (2008–2011).
Board Member, Italian Foundation for Liver Research (FIRE) (2013–2017).
Assistant Editor, Journal of Hepatology (2009–2011).
Associate Editor, Liver International (2014–2019).
Editorial Board Member, Hepatoma Research (2018–present).
Member, AVEN Ethics Committee (2018–2021).
MAIN RESEARCH INTERESTS
Cell-mediated immunity in HBV and HCV infection; viral persistence and immune clearance; T-cell responses against hepatocellular carcinoma; NK-cell biology and metabolism; immune dysfunction in chronic viral hepatitis and liver cancer; immunotherapeutic strategies for hepatocellular carcinoma.
CLINICAL TRIALS
Principal Investigator in multiple Phase II and III clinical trials in hepatocellular carcinoma, chronic viral hepatitis and COVID-19, including studies sponsored by Bracco Imaging, Gilead Sciences, Swedish Orphan Biovitrum, ReiThera and Inserm-ANRS.
RESEARCH GRANTS
Principal Investigator of competitive grants funded by the Italian Ministry of Health, AIRC, Cancer Research UK, PRIN and the University of Parma. Collaborator in multiple European Framework Programme and PNRR projects.
PATENTS
1992 – Inventor of "Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus".
2022 – Inventor of a patent on metabolic and functional restoration of NK cells in hepatocellular carcinoma.
TEACHING
Extensive teaching activity in undergraduate Medicine, Midwifery, postgraduate residency training in Infectious Diseases, and supervision of medical, biological sciences and biotechnology students. Director of national and international postgraduate courses in hepatology and liver immunology.
CLINICAL EXPERTISE
Management of infectious diseases and liver diseases; advanced liver ultrasound; contrast-enhanced ultrasound (CEUS); image-guided biopsies and aspirations; treatment of liver abscesses and hydatid cysts; percutaneous ethanol injection; radiofrequency and microwave ablation; multidisciplinary management of hepatocellular carcinoma; upper gastrointestinal endoscopy.
TECHNICAL EXPERTISE
Flow cytometry, T- and NK-cell functional assays, cellular metabolism analysis, T-cell cultures, viral sequencing, gene expression profiling and molecular immunology.
SCIENTIFIC OUTPUT
175 peer-reviewed publications
Scopus H-index: 63
Citations: 14,552
