- Curriculum Vitae
Franco Bisceglie was born in Cremona (Italy) on august 14, 1972. He graduated from the University of Parma in 1997 with a thesis entitled “Synthesis of SNO coordinating systems owning a biological activity”. From the same institution he received his PhD degree with a doctoral thesis entitled “Preparative, spectral and structural studies of new metal complexes with polydentate ligands of medical applicative interest”. He also worked worked on a research project for the “Synthesis of Tripodal Ligands C-centred. Preparation, Characterization, Reaction with Superoxide of the Corresponding Fe(II) and Mn(II) Complexes and Biological Activity” at the Laboratoire de Chimie Bioorganique et Bioinorganique (LCBB) of the Institut de Chimie Moléculaire et des Matérieux d’Orsay (ICMMO) at Paris XI University in the group of prof. I. Morgenstern-Badarau and under the supervision of prof. F. Lambert. He was recipient of two fellowships advertised by the “Inter-university consortium for the study of metals in biological systems (C.I.R.C.M.S.B.) to perform research projects in the field of “Metal ions in human diagnostic and therapy” and “ New inorganic drugs in oncology”. He was also appointed for several projects for the research, synthesis and characterization of non-cisplatin like metal complexes as anti-tumor agents.
In 2004 he obtained cum laude a Master of Science in “Quality Control and Chemical Analysis Methods Validation” with a thesis entitled “Validation of an analytical method and experimental design for products in stability studies: two critical aspects in the drug research, improvement and revisions for processes optimization”.
IHe became a researcher in 2005 and associate professor in 2015 at the University of Parma for the SSD CHIM03, having also obtained the National Scientific Habilitation for the CHIM07 sector.
His work currently focuses on the synthesis and characterization of metal complexes with bidentate and polydentate ligands, belonging in particular to the thiosemicarbazones class. He mainly studies the coordination properties related to the metals of the first transition series. He also deals with the verification through spectroscopic techniques of the interactions of the synthesized complexes with biological substrates to evaluate their interaction, studying for example the scavenging properties of radicals or the interactions with DNA or small proteins. The syntheses of organic-inorganic multicomponent systems under study were designed and developed and then characterized with spectroscopic and diffractometric methods. The study of their molecular structure was developed as a basis for the interpretation of their chemical reactivity towards biological systems. The relationship between structure and biological activity was studied and the research on the chelating behavior and steric and electronic properties of polyfunctional ligands such as aromatic and aliphatic thiosemicarbazones of molecules of biological interest was also investigated. His interest has also recently shifted to the synthesis of metal complexes with antibacterial properties that can play a contribution in reducing antibiotic resistance, and to the identification of molecules with antifungal or antiaflatoxigenic activity.
He also deals with the design and construction of new materials or modifications of existing materials for engineering applications, evaluating their design and industrial transfer as well as structural properties and environmental impact and also of innovative materials for advanced analytical applications.
He was a member of the Board of Directors of the University of Parma and chaired the Commission for the allocation of funds to Student Associations. He was also a member of the college of Discipline of the University of Parma.
Starting from the A.Y. 2016/2017 is RAQ (Quality Assurance Manager) of teaching for the Bachelor's Degree Course in Chemistry and is part of the GdR (Review Group) for the same degree course. Between 2015 and 2017 he was RAQ of Research for the Department of Chemistry.
He participated in the following PRIN calls admitted for funding:
"Design of thiosemicarbazone and triazole copper (II) complexes and evaluation of the mechanism underlying the apoptotic and non-apoptotic cytotoxic effect" (2007)
and "Innovative Analytical Methods to study biogenic and anthropogenic proxies in Ice COres (AMICO)" (2017).
He also took part in the three-year project (2015-2018) funded by the Cariplo Foundation "A biotechnological approach for the development of new antifungal drugs for the protection of the environment and human health".
He is member of the Editorial Board of the journals "Molecules" and "Compounds" (MDPI).
He is referee for many journals in the inorganic and bioinorganic area.
He is "expert evaluator" for the National Center of Science and Technology (Kazakhstan) and for the National Science Center (Poland).
He is part of the Doctoral board in Chemical Sciences of the University of Parma.
It is part of the CIRCMSB - Interuniversity Consortium for Research in Chemistry of Metals in Biological Systems and of the following Centers: CERT - Center of Excellence for Toxicological Research and COMT - Interdepartmental Research Center for Molecular and Translational Oncology.
At the date of January 18, 2021 (SCOPUS) Franco Bisceglie is author of 56 publications, and many presentations at congresses.
His ORCID id is 0000-0001-9165-0356.
His h index is 26 and he has received 2130 citations.
Anno accademico di erogazione: 2023/2024
Anno accademico di erogazione: 2022/2023
Anno accademico di erogazione: 2021/2022
Anno accademico di erogazione: 2020/2021
Anno accademico di erogazione: 2019/2020
Anno accademico di erogazione: 2018/2019
Anno accademico di erogazione: 2017/2018
Anno accademico di erogazione: 2016/2017
Anno accademico di erogazione: 2015/2016
- First cycle degree (DM 270) BIOLOGY A.Y. 2023/2024
- First cycle degree (DM 270) BIOLOGY A.Y. 2022/2023
- First cycle degree (DM 270) BIOLOGY A.Y. 2021/2022
- First cycle degree (DM 270) BIOLOGY A.Y. 2020/2021
- First cycle degree (DM 270) CHEMISTRY A.Y. 2019/2020
- First cycle degree (DM 270) CHEMISTRY A.Y. 2018/2019
- First cycle degree (DM 270) CHEMISTRY A.Y. 2017/2018
- First cycle degree (DM 270) CHEMISTRY A.Y. 2016/2017
- First cycle degree (DM 270) CHEMISTRY A.Y. 2015/2016
Gold(III) complexes with thiosemicarbazone ligands: insights into their cytotoxic effects on lung cancer cellsYear: 2024Author/s: Scaccaglia Mirco, Pinelli Silvana, Manini Luca, Ghezzi Benedetta, Nicastro Maria, Heinrich Julian, Kulak Nora, Mozzoni Paola, Pelosi Giorgio, Bisceglie Franco
Allium cepa tests: a plant-based tool for the early evaluation of toxicity and genotoxicity of newly synthetized antifungal moleculesYear: 2023Author/s: Alias C., Feretti D., Viola G. V. C., Zerbini I., Bisceglie F., Pelosi G., Zani C., Buschini A., Carcelli M., Rogolino D., Restivo F. M., Degola F.
Modulation of Transcription Profile Induced by Antiproliferative Thiosemicarbazone Metal Complexes in U937 Cancer CellsYear: 2023Author/s: Montalbano Serena, Bisceglie Franco, Pelosi Giorgio, Lazzaretti Mirca, Buschini Annamaria
Year: 2023Author/s: Valentino Roberto, Bisceglie Franco, Romeo Elena
Antiproliferative Activity and DNA Interaction Studies of a Series of N4,N4-Dimethylated Thiosemicarbazone DerivativesYear: 2023Author/s: Montalbano Serena, Buschini Annamaria, Pelosi Giorgio, Bisceglie Franco