Prof.

MENOZZI Alessandro

Professore di II fascia
  • Curriculum Vitae
  • Teaching
  • Appointments
  • Research

BIRTH DATE: June 5, 1964

BIRTH PLACE: Savona, Italy

EDUCATION

1990 D.V.M.; Summa cum laude, University of Parma
1990-2002 Veterinary Medicine practitioner in the field of companion animals
2002-2006 Contract with the University of Parma for research work in the Section of Pharmacology of the Faculty of Medicine and Surgery
2006 PhD in Pharmacology and Toxicology (Faculty of Medicine and Surgery, University of Padova)
2007-2014 Assistant Professor (Unit of Pharmacology and Toxicology), Faculty of Veterinary Medicine, University of Parma
2014 Associate Professor of Veterinary Pharmacology (Unit of Pharmacology and Toxicology), Department of Veterinary Science, University of Parma

Teaching activity (Degree course in Veterinary Medicine, University of Parma)

Pharmacokinetics: Overview. Transport of drugs across membranes. Absorption, distribution, metabolism and excretion of drugs. Bioavailability. Volume of distribution. Plasma concentration curves. Drug half-life. Pharmacokinetic models. First- order and saturation kinetics.
Pharmacodynamics: Receptors. Drug-receptor interactions. Concentration- response curves. Agonists, antagonists and inverse agonists. Concept of LD50, ED50, drug safety and therapeutic index.
Drugs affecting different systems and organs.

Research fields:

1. Clinical efficacy of rifaximin and new therapeutic approaches in chronic enteropathies of small animals
2. Effects of drugs (NSAIDs, opioid analgesics, alpha-2 agonists, muscarinic antagonists) on bronchial and intestinal motility “in vitro” in horses
3. Detection of contaminants (lead and copper derived from hunting ammunitions) in game meat
4. HPLC analysis of antibiotic and antiparasitic drugs in plasma and tissues

Publications:
1) Poli E, Menozzi A, Pozzoli C, Coruzzi G, Kitbunnadaj R, Timmermann H, Leurs R.
Functional characterisation of the novel histamine H(3) receptor agonist, VUF 5810,
on the guinea-pig isolated ileum. (2004) Inflamm Res 53 (Suppl 1):S77- 78. ISSN: 1023-3830.
2) Coruzzi G, Menozzi A, Dobrilla G. Novel non-steroidal anti-inflammatory drugs: what we have learned from animal studies. (2004) Curr Drug Targets Inflamm Allergy 3:43-61. ISSN: 1389-4501.
3) Menozzi A, Pozzoli C, Poli E, Lazzaretti M, Cantoni A, Grandi D, Giovannini E, Coruzzi G. Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat. (2005) Pharmacology 74:135-142. ISSN: 0031-7012.
4) Kitbunnadaj R, Hashimoto T, Poli E, Zuiderveld O, Menozzi A, Hidaka R, de Esch I, Bakker R, Menge W, Yamatodani A, Coruzzi G, Timmerman H, Leurs R. N-substituted piperidinyl alkyl imidazoles: discovery of methimepip as a potent and selective histamine H3 receptor agonist. (2005) J Med Chem 48:2100-2107. ISSN: 0022-2623.
5) Morini G, Poli E, Comini M, Menozzi A, Pozzoli C. Benzisothiazoles and beta-adrenoceptors: synthesis and pharmacological investigation of novel propanolamine and oxypropanolamine derivatives in isolated rat tissues. (2005) Arch Pharm Res 28:1317-1323. ISSN: 0253-6269.
6) Adami M, Coppelli G, Guaita E, Pozzoli C, Menozzi A, Giovannini E, Coruzzi G. Effects of cyclooxygenase-1 and -2 inhibition on gastric acid secretion and cardiovascular functions in rats. (2006) Pharmacology 76:84-92. ISSN: 0031-7012.
7) Coruzzi G, Adami M, Guaita E, Menozzi A, Bertini S, Giovannini E, Soldani G. Effects of cannabinoid receptor agonists on rat gastric acid secretion: discrepancy between in vitro and in vivo data. (2006) Dig Dis Sci 51:310-317. ISSN: 0163-2116.
8) Menozzi A, Pozzoli C, Giovannini E, Solenghi E, Grandi D, Bonardi S, Bertini S, Vasina V, Coruzzi G. Intestinal effects of nonselective and selective cyclooxygenase inhibitors in the rat. (2006) Eur J Pharmacol 552:143-150. ISSN: 0014-2999.
9) Menozzi A, Pozzoli C, Poli E, Lazzaretti M, Grandi D, Coruzzi G. Long-term study of TNBS-induced colitis in rats: Focus on mast cells. (2006) Inflamm Res 55:416-422. ISSN: 1023-3830.
10) Pozzoli C, Menozzi A, Grandi D, Solenghi E, Ossiprandi MC, Zullian C, Bertini S, Cavestro GM, Coruzzi G. Protective effects of proton pump inhibitors against indomethacin-induced lesions in the rat small intestine. (2006) Naunyn Schmiedebergs Arch Pharmacol 374:283-291.
11) Menozzi A, Pozzoli C, Poli E, Dacasto M, Giantin M, Lopparelli RM, Passeri B, Zullian C, Gobbetti T, Bertini S. Effects of nonselective and selective cyclooxygenase inhibitors on small intestinal motility in the horse. (2008) Res Vet Sci 86:129-135. ISSN: 0034-5288.
12) Serventi P, Zullian C, Menozzi A, Amicabile A, Botti P, Martelli M, Bertini S. Determinazione della curcumina nel plasma di suino mediante metodica HPLC. (2008) Annali della Facoltà di Medicina Veterinaria di Parma 28:105-112.
13) Menozzi A, Pozzoli C, Poli E, Martelli M, Martelli L, Zullian C, Bertini S. Effects of oral curcumin on indomethacin-induced small intestinal damage in the rat. (2009) Drug Discov Ther 3:71-76. ISSN: 1881-7831.
14) Zullian C, Menozzi A, Pozzoli C, Poli E, Bertini S. Effects of alpha(2)-adrenergic drugs on small intestinal motility in the horse: An in vitro study. (2010) Vet J 187:342-346.
15) Menozzi A, Pozzoli C, Poli E, Passeri B, Gianelli P, Bertini S. Diazoxide attenuates indomethacin-induced small intestinal damage in the rat. (2011) Eur J Pharmacol 650:378-383.
16) Menozzi A, Pozzoli C, Zullian C, Poli E, Serventi P, Bertini S. Inhibition of motility in isolated horse small intestine is mediated by κ but not μ opioid receptors. (2012) Equine Vet J 44:368-370.
17) Galluzzi F, De Rensis F, Menozzi A, Spattini G. Effect of intraurethral administration of atracurium besylate in male cats with urethral plugs. (2012) J Small Animal Practice 53:411-415.
18) Adami M, Pozzoli C, Menozzi A, Bertini S, Passeri B, Cantoni AM, Smits R, De Esch I, Leurs R, Coruzzi G. Effects of histamine H 4 receptor ligands in a mouse model of gastric ulceration. (2012) Pharmacology 89:287-294.
19) Mazzoni C, Sabbioni A, Bertini S, Menozzi A, Piancastelli C, Catelli E, Zanardelli P, Zambini EM, Saleri R, Superchi P. Estudio preliminar de la utilización de la cafeína en las cerdas en el momento del parto. (2012) Suis 90:32-35.
20) Menozzi A, Pozzoli, C, Poli, E, Delvescovo B, Serventi p, Bertini S. Pharmacological characterisation of muscarinic receptors in the contractions of isolated bronchi in the horse. (2014) Journal of Veterinary Pharmacology and Therapeutics 37:325-331, ISSN: 1365-2885, doi: 10.1111/jvp.12108.
21) Menozzi A, Mazzoni C, Serventi P, Zanardelli P, Bertini S. Pharmacokinetics of oral caffeine in sows: a pilot study. (2015) Large Animal Review 21:207-210, ISSN: 1124-4593.
22) Menozzi A, Bertini S, Turin L, Serventi P, Kramer LH, Bazzocchi P. Doxycycline levels and anti-Wolbachia antibodies in sera from dogs experimentally infected with Dirofilaria immitis and treated with a combination of ivermectin/doxycycline. (2015) Veterinary Parasitology 209:281-284, ISSN: 0304-4017, doi: 10.1016/j.vetpar.2015.02.023.
23) Menozzi A, Dall'Aglio M, Quintavalla F, Dallavalle L, Meucci V, Bertini S. Rifaximin is an effective alternative to metronidazole for the treatment of chronic enteropathy in dogs: a randomised trial. (2016) BMC Veterinary Research 12, ISSN: 1746-6148, doi: 10.1186/s12917-016-0851-0.
24) Quintavalla F, Menozzi A, Pozzoli C, Poli E, Donati P, Wyler DK, Serventi P, Bertini S. Sildenafil improves clinical signs and radiographic features in dogs with congenital idiopathic megaoesophagus: a randomised controlled trial. (2017) Veterinary Record 180:404, ISSN: 0042-4900, doi: 10.1136/vr.103832.
25) Menozzi A, Pozzoli C, Poli E, Bontempi G, Serventi P, Meucci V, Intorre L, Bertini S. Role of muscarinic receptors in the contraction of jejunal smooth muscle in the horse: An in vitro study. (2017) Research in Veterinary Science 115:387-392, ISSN: 0034-5288, doi: 10.1016/j.rvsc.2017.07.012.
26) Menozzi A, Dall’Aglio M, Quintavalla F, Meucci V, Bertini S. Rifaximin induces and maintains clinical remission in a dachshund with chronic enteropathy: antibiotic-responsive diarrhoea or inflammatory bowel disease? (2017) Veterinary Record Case Reports 5, ISSN: 2052-6121, doi: 10.1136/vetreccr-2016-000423.
27) Menozzi A, Pozzoli C, Poli E, Colla C, Placenza G, Bertini S. Effects of selective α2-adrenergic receptor agonists on electrical field-stimulated contractions of isolated bronchi in horses. (2018) Journal of Veterinary Pharmacology and Therapeutics 41:246-253, ISSN: 1365-2885, doi: 10.1111/jvp.12470.

Completion accademic year: 2019/2020

Completion accademic year: 2018/2019

Completion accademic year: 2017/2018

Completion accademic year: 2016/2017

Completion accademic year: 2015/2016

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