Personale docente

STUDIES AND ACADEMIC CAREER
• March 2019 to present: Associate Professor in the CHEM-03/A sector (formerly CHIM/03) “General and Inorganic Chemistry” at the University of Parma, affiliated with the Department of Chemical, Life, and Environmental Sustainability Sciences.
• September 2002 – February 2019: Tenured University Researcher in the CHIM/03 sector “General and Inorganic Chemistry” at the University of Parma, affiliated with the Department of Chemical, Life, and Environmental Sustainability Sciences.
• 2001: Ph.D. in Chemical Sciences, thesis titled “Metal complexes of α-amino acid derivatives: studies in solution and in the solid state” - University of Parma (advisor: Prof. Francesco Dallavalle).
• 1993-1998: Graduated with honors from the University of Parma (advisors Prof. Marina Cingi Biagini and Prof. Maurizio Lanfranchi); thesis on “Ru(II) and Ru(III) complexes with aminotriazole ligands.” Awarded the University’s prize for best student in Chemistry in the 1997/98 academic year.
RESEARCH AND STUDY ABROAD
• 2010 and 2012: Two six-month research periods at the Department of Chemistry, University of Michigan (Ann Arbor, USA). Project: de novo-designed copper-containing metallopeptides, in collaboration with Prof. Vincent Pecoraro.
• 2008 - 2009: Six-month research period at the University of Michigan (Ann Arbor, USA). Project: metallacrowns as recognition agents for cations, in collaboration with Prof. Vincent Pecoraro.
• 2001: Visiting Ph.D. student at the Technical University of Lisbon (Instituto Superior Tecnico, Portugal). Project: synthesis of hydroxamate inhibitors of matrix metalloproteinases (advisor: Prof. M. Amelia Santos Seabra).
• 1998: Erasmus student at Leiden University (Netherlands). Laboratory research in preparation for the undergraduate thesis. Project: ruthenium complexes as novel antitumor drugs (advisor: Prof. Jan Reedijk).
RESEARCH ACTIVITIES
My research focuses on studying the equilibria involved in the formation of metal complexes in solution. This work spans bioinorganic chemistry and supramolecular chemistry, with expertise in the thermodynamics and kinetics of metal complex formation, metal-ligand speciation in solution, and, more recently, catalysis of oxidation reactions promoted by metal complexes. The general aim of my studies is to elucidate the relationship between structural characteristics, solution stability, and the physicochemical and biological properties of metal complexes. My research has covered three primary areas: (1) the study of metallacrown chemistry, (2) the study of metal complexes with peptides and protein models, and (3) the study of metal complexes with antiproliferative and antitumor properties.
• The first project focuses on a class of metallamacrocycles known as metallacrowns, for which I contributed to clarifying the thermodynamics and kinetics of self-assembly in solution.
• The second research area involves the speciation of metal/peptide systems, where the peptides serve both as models of artificial proteins and as relevant peptides in the development of neurodegenerative diseases.
• The third project involves collaboration in developing antitumor complexes, establishing methods to study their stability in non-aqueous solvents to correlate solution speciation with their reactivity in biological systems.
As of November 3, 2024, my scientific output includes 73 publications in international peer-reviewed journals indexed on Web of Science or Scopus (2525 citations, h-index = 28), and one patent. I have delivered 34 presentations at national and international conferences and meetings (9 invited), 6 invited seminars, and over 40 poster presentations as first author. I have been a member of various international, national, and regional scientific associations and committees, and have contributed as an organizer and scientific committee member to numerous public events, conferences, and outreach activities for the general public and schools.

MAIN RESEARCH LINES

- DEVELOPMENT OF METALLACROWN CHEMISTRY

The field of metallamacrocycle design and self-assembly has expanded significantly over the past two decades. My primary research contribution in this field has been to elucidate several aspects of the solution chemistry of a class of molecules called metallacrowns. Metallacrowns (MCs) are a class of cyclic supramolecular complexes in which bridging ligands (e.g., aminohydroxamates) coordinate with metal ions to form planar structures. These molecules feature a cavity, similar to that found in crown ethers, capable of coordinating transition, alkaline-earth, lanthanide, or actinide metal ions. The properties of the metal ions and ligands used (coordination geometry, preorganization, etc.) enable control over the geometry and dimensions of the metallamacrocycles during assembly. Metallacrowns are characterized by a relatively high number of metal ions confined within a small coordination construct, giving them unique magnetic (single-molecule magnets), optical, luminescent, catalytic, and molecular recognition properties for cations and anions. Additionally, they can serve as building blocks for isolating coordination polymers.
My research on MCs primarily focuses on studying the thermodynamics and kinetics of their self-assembly, as well as their physicochemical properties in solution as a function of the ligands used. Except for the most recent results, the findings from this research line have been summarized in a review, for which I am the corresponding author, detailing the key thermodynamic aspects of self-assembly and host-guest equilibria of copper-based metallacrowns in solution (Tegoni M. et al., Coord. Chem. Rev. 256, 289–315 (2012)).
During my PhD, I initially investigated the thermodynamic stability of ternary copper(II) complexes with hydroxamic and chiral amino acid derivatives to achieve enantioselective discrimination of the latter (Dallavalle, F., Tegoni M. et al., Polyhedron 20, 103–109 (2001)). Through detailed studies, we verified that the Cu(II)/α-aminohydroxamate speciation reported in the literature and accepted for over 20 years was incorrect. Specifically, we demonstrated the unexpected formation of metallacrowns at specific pH values for these ligands (Dallavalle, F.; Tegoni, M., Polyhedron 20, 2697–2704 (2001); Careri, M., Tegoni M. et al., J. Inorg. Biochem. 93, 174–180 (2003); Tegoni, M. et al., Dalton Trans. 1329–1333 (2004)). Our observations contrasted with the model linking metallacrown stability to ligand geometry (known in the literature as the "metallacrowns structural paradigm") and inspired my subsequent research. By studying the thermodynamic stability of MCs in solution, I established that metallacrown formation is not limited to ligands whose geometry meets the structural paradigm, but also occurs with different ligands, and that ligand geometry indeed influences MC stability (Tegoni, M. et al., Chem. Eur. J. 13, 1300–8 (2007); Tegoni, M. et al., Dalton Trans. 2693–701 (2008)). This research resulted in the development of a more general structural paradigm for metallacrowns (as described in the 2012 review) and a self-assembly mechanism supported by kinetic studies on the copper(II)/α-alanine hydroxamic acid system (Beccia, M. R., Tegoni M. et al., Dalton Trans. 43, 9271–82 (2014)).
Later, I extended my research to metallacrowns containing lanthanide ions in the cavity, as they exhibit unique properties as receptors for cations and anions, as well as magnetic and luminescent properties. My studies on the thermodynamic stability and formation kinetics of these compounds highlighted two main characteristics: 1) lanthanide MCs are highly stable over a wide pH range and are not susceptible to decomposition due to metal hydroxide formation at high pH (Dallavalle, F., Tegoni M. et al., Inorg. Chem. 49, 1761–72 (2010)); 2) lanthanides are complexed by MCs with stability orders of magnitude greater than crown ethers. Additionally, MCs show greater thermodynamic and kinetic selectivity for lanthanide size compared to crown ethers, making them potential complexing agents for the separation of cations with large ionic radii (Tegoni M. et al., Inorg. Chem. 49, 5190–201 (2010); Lim, C.-S., Tegoni M. et al., Inorg. Chem. 51, 11533–11540 (2012)). Finally, I have studied the anion receptor properties of lanthanide-containing MCs, demonstrating their ability to act as anion recognition agents in solution (Tegoni M. et al., Dalton Trans. 6705–8 (2009); Sgarlata C., Tegoni, M. et al., Chem. Eur. J. 2021, 27, 17669–75 (2021); Salerno E. V.; Tegoni M. et al., Eur. J. Inorg. Chem. e202200439 (2022)).
Alongside my studies on copper(II) MCs, I also investigated the thermodynamics of MC formation with Ni(II) and Zn(II) ions, as these are of interest for lanthanide reception and luminescent MC preparation, respectively. Regarding Ni(II) MCs, their formation thermodynamics differ significantly from those of Cu(II) analogs. In particular, I demonstrated that with Ni(II), it is possible to assemble vacant MCs (i.e., with an empty cavity) that exhibit strong cation recognition properties (Bacco, D., Tegoni M. et al., Dalton Trans. 40, 2491–501 (2011); Remelli, M., Tegoni M. et al., Dalton Trans. 42, 8018–25 (2013)). Conversely, Zn(II)/α-aminohydroxamate systems have a speciation model analogous to that of Cu(II), despite the differences in coordination geometry preferences between the cations (Marchiò, L., Tegoni M. et al., Dalton Trans. 44, 3237–3250 (2015)).
Over the past five years, corresponding with the start of a European project under my coordination, I have pursued research into metallacrowns as building units for constructing coordination polymers and three-dimensional porous networks. These studies led to the isolation of the first 3D construct capable of exhibiting permanent porosity (Atzeri, C., Tegoni M. et al., Chem. Eur. J. 22, 6482–6486 (2016)) and the first 3D MOF-like coordination polymer based on metallacryptates (Marzaroli V., Tegoni M. et al., Three-dimensional porous architectures based on MnII/III three-blades paddlewheel metallacryptates, submitted (2018)). In this field, I have also established collaborations aimed at studying the solution integrity of transition metal metallacryptates (Lamberts, K., Tegoni M. et al., Dalton Trans. 45, 284–295 (2016)).
Recently, my research group has also focused on elucidating the paramagnetic properties of Ln(III) complexes with salicylhydroxamic ligands and trivalent metals in the scaffold, correlating NMR properties with the chemical-physical parameters of the complex, especially the lanthanide crystal field splitting. Specifically, we have shown that the scaffold of 12-MC-4 lanthanides is highly fluxional in solution (Atzeri, C., Tegoni M. et al., Inorg. Chem. 56 (14), 8257–8269 (2017); Melegari M.; Tegoni, M. et al., Inorg. Chem. 62, 10645–54 (2023); Melegari M., Tegoni, M. Aspects of NMR Characterization of Metallacrowns. In Advances in Metallacrown Chemistry; 37–76, (2022)).
In this research area, I am the author of 24 publications, 15 as corresponding author. I have coordinated two international projects: Marie Curie IRSES “Metallacrowns” (EU 7th Framework Programme) and the Italy-USA Bilateral Project of Great Relevance (2016-2018). I presented these findings in 22 oral presentations at conferences and seminars, including five invited seminars and three invited conference talks. Additionally, I spent six months on a research sabbatical at the University of Michigan (Ann Arbor, USA) to conduct experimental research (2008 and 2009) and was the organizer and chairman of the 1st International Symposium on Metallacrowns and Metallacryptates (Parma, September 28-29, 2017).

- METALS IN BIOLOGICAL SYSTEMS: DESIGN OF ARTIFICIAL METALLOPROTEINS AND METALS IN NEURODEGENERATIVE DISEASES

A significant part of my research, beginning in 2004 as part of a national project on animal nutrition, focused on the thermodynamics of metal complex formation in solutions with peptides and amino acid derivatives (Predieri, G., Tegoni M. et al., J. Inorg. Biochem. 95, 221–224 (2003); Predieri, G., Tegoni M. et al., J. Inorg. Biochem. 99, 627–36 (2005); Ferretti, L., Tegoni M. et al., J. Inorg. Biochem. 101, 1442–1456 (2007)).
In subsequent years, I expanded the study of metal complex formation equilibria in solution to include de novo designed copper(II)/peptide systems. De novo design of peptides or proteins is a bottom-up approach using simplified synthetic polypeptide constructs to recreate coordination sites similar to those in natural metalloproteins. In these molecules, a significant portion of the protein structure is ideally removed, yet sufficient structural complexity is retained to display functionality analogous to a natural protein. My research, conducted in collaboration with a U.S. partner where I spent a year, initially focused on the design and synthesis of a self-assembled triple helix construct containing a type-2 copper center using a peptide sequence named TRI. These synthetic constructs incorporate a Cu(His)3 site and possess two notable features: copper is stably coordinated both as copper(I) and copper(II), and the metallopeptide exhibits nitrite reductase-like catalytic activity, producing nitric oxide selectively from nitrite ions (Tegoni, M. et al., Proc. Natl. Acad. Sci. U.S.A. 109, 21234–21239 (2012); Yu, F., Tegoni M. et al., Chem. Rev. 114, 3495–578 (2014)). This research was funded by an Italy-USA Bilateral Project of High Relevance from 2011-2012. In this context of artificial metal-peptide systems, I also studied peptides containing ATCUN (Amino-Terminal Cu and Ni binding sites) covalently linked to an organic platform. The high local concentration of these branched peptides enabled the formation of copper(II) coordination systems that are not achievable with isolated peptide chains (Perinelli M., Tegoni M. et al., J. Inorg. Biochem. 205, 110980 (2020)).
Since 2021, I have started a new project focused on designing metalloproteins using the Spy construct. Spy is an artificial protein redesigned from the CnaB2 domain of a fibronectin binding protein from Streptococcus Pyogenes, hence the acronym Spy. Spy consists of two components: a protein (SpyCatcher) and a peptide (SpyTag). The protein component is a beta-sandwich protein of approximately 110 amino acids, while the second component is a peptide of about 15 amino acids containing a consensus IVMVD sequence that interacts in a lock-and-key manner with SpyCatcher. These two components uniquely bind through an autocatalytic reaction between the aspartate residue in the Tag consensus sequence and a lysine residue in Catcher, forming an isopeptide bond. This spontaneous and irreversible reaction occurs in solution at room temperature within minutes, resembling a click reaction. This approach ideally shifts the complexity of designing or introducing an artificial catalytic site from a protein to a peptide. This project is conducted in collaboration with a molecular biology group at the University of Parma, which handles the expression of the SpyCatcher protein, while SpyTag peptides are synthesized on a solid phase in my research labs.
An initial artificial metalloprotein was created by adding an ATCUN sequence (Gly-Ser-His) to SpyTag upstream of the IVMVD consensus sequence. The ATCUN sequence provides SpyTag with a femtomolar affinity for Cu(II). This high affinity is retained even when SpyTag is combined with SpyCatcher to reconstitute the Spy protein: the first equivalent of Cu(II) added to the protein selectively binds to the ATCUN fragment, and only after this site is saturated does excess Cu(II) bind to the N-terminal of SpyCatcher. These results demonstrate that specific metal-binding sequences on the SpyTag peptide enable the selective incorporation of metal sites into the Spy protein construct. These findings were presented at various conferences (ISMEC 2021 International Symposium on Thermodynamics of Metal Complexes; Białystok, Poland, 2021; 2nd European COST NECTAR Conference; Lisbon, Portugal, 2021; Artificial Proteins in the 21st Century: Designed (Metallo) Proteins, Marseille, France, 2022 (invited); MBP 2022 1st International Conference on Metal-Binding Peptides. Nancy, France, 2022 (invited); ISMEC 2023 International Symposium on Metal Complexes, Urbino, Italy, 2023; MBP 2024 2nd International Conference on Metal-Binding Peptides, Toulouse, France, 2024 (invited); EUROBIC 17 European Conference in Bioinorganic Chemistry; Münster, Germany, 2024) and are currently under review in an international journal.
Following the introduction of the ATCUN fragment, we designed SpyTag peptides containing the His-His fragment to introduce the Cu(II)(His)2 catalytic system into the Spy protein. This coordination center, known to promote aerobic oxidation of catechols, was selected to demonstrate that a catalytic redox-active metalloprotein could be constructed using this approach. Our findings confirm that the metal site is capable of catalyzing catechol oxidation even when embedded in the protein and shows a slight stereoselective effect in the oxidation rates of D- and L-DOPA enantiomers used as substrates. These results were presented at international conferences (MBP 2022 1st International Conference on Metal-Binding Peptides. Nancy, France, 2022 (invited); ISMEC 2023 International Symposium on Metal Complexes, Urbino, Italy, 2023; MBP 2024 2nd International Conference on Metal-Binding Peptides, Toulouse, France, 2024 (invited); EUROBIC 17 European Conference in Bioinorganic Chemistry; Münster, Germany, 2024).
Currently, I am the Principal Investigator for a project funded by the PNRR, titled "Artificial Enzymes for Photocatalytic Hydrogen Production in Photosynthetic Bacteria" (PNRR ART-2-HYDROGEN “ARTIFICIAL ENZYMES FOR PHOTOCATALYTIC HYDROGEN PRODUCTION IN PHOTOSYNTHETIC BACTERIA” ID: RSH2A_000009, Italian Ministry of Environment and Energy Security). This project aims to use Spy technology to decorate the outer membrane of cyanobacteria with photoactivatable metal complexes and catalytic centers capable of producing hydrogen. To date, we have anchored ruthenium and iridium complexes to the SpyTag peptide and identified a dinuclear nickel(II) complex capable of reducing water to hydrogen gas even when inserted into the Spy protein. These recent results, achieved in collaboration with researchers from the University of Ferrara, were presented at the EUROBIC-17 conference (EUROBIC 17 European Conference in Bioinorganic Chemistry; Münster, Germany, 2024).
Since 2016, I have collaborated with researchers at the Universities of Pavia and Ferrara on characterizing Cu(II) metal complexes with peptide fragments that mimic binding sites in α-Synuclein and Tau proteins, relevant to neurodegenerative diseases. My research group focused on studying formation equilibria in Cu(II) and Cu(I) systems with oligopeptides containing the (His)2 fragment. These studies clarified the coordination environment of copper in both oxidation states, elucidating the probable stability of Cu(II) and Cu(I) complexes at this site. This work is part of the PRIN 2015 project “Metal ions, dopamine, and oxidative stress in Parkinson's disease,” for which I serve as a local unit coordinator (Casella, L., Bubacco, L.; Valensin, D.; Tegoni, M., Impact 2017 (6), 9–11 (2017); Bacchella, C.; Tegoni, M. et al., Inorg. Chem., 59 (1), 274–286 (2020); Bacchella, C.; Tegoni, M. Int. J. Mol. Sci., 23 (18), (2022)). In collaboration with these research groups, we are currently studying SpyTag peptides containing histidines capable of binding heme groups to introduce heme into the Spy protein and evaluate its peroxidase activity. This research is conducted within the PRIN 2022 project "Bioinspired systems for ROS regulation: metalloporphyrinoids in neurodegeneration and artificial biocatalysis," for which I am also a local unit coordinator.
In connection with these lines of research, I collaborated with researchers at the University of Parma to investigate the stability of copper(II) complexes with tripodal ligands as models for cupredoxins. My contribution to this project involved studying the stability of these complexes in solution using potentiometric, spectrophotometric, and NMR techniques. The results concerning solution equilibria were used to clarify the electrochemical, structural, and spectroscopic behavior of these model complexes (Gennari, M., Tegoni M. et al., Polyhedron 23, 1829–1835 (2004); Gennari, M., Tegoni M. et al., Inorg. Chem. 45, 3456–3466 (2006); Gennari, M., Tegoni M. et al., Inorg. Chem. 46, 3367–77 (2007); Gennari, M., Tegoni M. et al., Inorg. Chem. 47, 2223–2232 (2008)).
In this line of research, I am the author of 12 publications in international journals, four of which are as corresponding author. I have presented the results of this project in 15 oral presentations at national and international conferences, including six invited talks.

- COPPER COMPLEXES AS ANTIPROLIFERATIVE AGENTS

As an additional line of research, I conducted studies on copper(II) complexes with triazole and thiosemicarbazone ligands exhibiting antiproliferative activity on cancer cell lines. This work was developed in collaboration with researchers from the Universities of Parma and Camerino, as well as the CNR in Padua. The complexes were analyzed in terms of structural characteristics, solution stability, and antiproliferative activity to clarify the correlation between their thermodynamic stability and activity. My contribution to this project demonstrated that high stability of the complexes does not correlate with increased activity, which is instead more closely related to the lipophilicity of the ligands. These ligands act as ionophores, allowing copper(II) to cross the cellular barrier. (Dallavalle, F.; Tegoni, M. et al., J. Inorg. Biochem. 92, 95–104 (2002); Ferloni, E.; Tegoni, M. et al., Inorg. Chim. Acta 358, 147–160 (2005); Gaccioli, F.; Tegoni, M. et al., J. Inorg. Biochem. 99, 1573–1584 (2005); Tardito, S.; Tegoni, M. et al., J. Med. Chem. 50, 1916–24 (2007); Tardito, S.; Tegoni, M. et al., J. Am. Chem. Soc. 133, 6235–42 (2011); Rogolino, D.; Tegoni, M. et al., Eur. J. Med. Chem. 128, 140–153 (2017); Carcelli, M.; Tegoni, M.; Eur. J. Med. Chem. 2020, 194, 112266; Carcelli, M.; Tegoni, M. et al., J. Biol. Inorg. Chem. 2023, 28 (1), 17–27; Zavaroni, A.; Tegoni, M. et al., Int. J. Mol. Sci. 2024, 25 (19), 10831; Miglioli, F.; Tegoni, M. et al., Eur. J. Med. Chem. 2024, 272, 116467).
In this area of research, I also collaborated with researchers from the Interuniversity Consortium for Research in Metal Chemistry in Biological Systems on the development of copper(I) complexes with phosphine and thioether ligands as antiproliferative and antitumor agents. I assessed the thermodynamic stability of these complexes in solution, even in the presence of competitive bioligands (Tisato, F.; Tegoni, M. et al., Rapid Commun. Mass Spectrom. 24, 1610–6 (2010); Aquilanti, G.; Tegoni, M. et al., Dalton Trans. 40, 2764–77 (2011); Tisato, F.; Tegoni, M. et al., J. Inorg. Biochem. 165, 80-91 (2016); Quaretti, M.; Tegoni, M. et al., J. Inorg. Biochem. 188, 50–61 (2018)).
Within the framework of this project, I have published 18 articles in international journals (four as corresponding author) and delivered two oral presentations at national and international conferences.

INTERNATIONAL, NATIONAL, AND LOCAL PROJECTS, AND FUNDING

2023-2025: Scientific lead for the PNRR project ART-2-HYDROGEN, "Artificial Enzymes for Photocatalytic Hydrogen Production in Photosynthetic Bacteria" (ID: RSH2A_000009), under Italy's National Recovery and Resilience Plan (PNRR) – Mission 2, "Green Revolution and Ecological Transition," Component 2, "Renewable Energy, Hydrogen, Network and Sustainable Mobility," Investment 3.5 "Research and Development on Hydrogen." Funded by the European Union – Next Generation EU via the Ministry of Ecological Transition’s decree on 23.12.2021. Total funding: EUR 2,142,500.
2024-2026: Supervisor for an HORIZON TMA MSCA Postdoctoral Fellowship - European Fellowships position (proposal 101152452; "Artificial Metalloenzymes Using SPY Protein, U-SPY"). Funded by the REA Research Executive Agency with EUR 188,590.
2023-2025: Scientific lead for the University of Parma project "Way Towards Artificial Metalloenzymes: Redesigned Catalysts and Tools to Understand Nanoscale Reactivity." Total funding: EUR 35,102.
2023-2025: Scientific lead for the local unit in the PRIN 2022 project "Bioinspired Systems for ROS Regulation: Metalloporphyrinoids in Neurodegeneration and Artificial Biocatalysis" (ID: 2022RCRWE5). Project coordinator: Prof. Simone Dell’Acqua, University of Pavia. Funded by the Ministry of Universities and Research (MUR) with EUR 66,115.
2016-2020: Local unit lead for the PRIN 2015 project "Metal Ions, Dopamine, and Oxidative Stress in Parkinson's Disease" (ID: 2015T778JW). Project coordinator: Prof. Luigi Casella, University of Pavia. Funded by MIUR with EUR 40,000.
2016-2018: Coordinator for the Italy-USA Bilateral Project of Major Relevance, "Development of Porous Magnetic Metallacrowns for Sensing Applications" (12th Italy-USA Science and Technology Conference). USA Partner: Prof. Vincent L. Pecoraro. Funded by the Ministry of Foreign Affairs with EUR 65,000. Project website.
2013-2017: Coordinator of the Marie Curie IRSES European Project "METALLACROWNS – Metallacrowns-based Innovative Materials and Supramolecular Devices," under the EU's 7th Framework Programme (2007-2013). Managed an international consortium of seven universities and research centers, including the Universities of Wroclaw, Poznan (PL), Paris-Sud (FR), Kiev (UA), Michigan (USA), and CNRS (FR). Total funding: EUR 193,000; University of Parma funding: EUR 63,300. Project information | Project website.
2011-2013: Coordinator of the Italy-USA Bilateral Project of Major Relevance, "De Novo Designed Metallopeptides to Mimic Structural and Catalytic Copper Sites in Metalloproteins" (10th Italy-USA Science and Technology Conference). USA Partner: Prof. Vincent L. Pecoraro. Funded by the Ministry of Foreign Affairs with EUR 9,000.
2004-2007: Participant in PRIN 2004 project "Synthesis and Characterization of Metal Chelates with Amino Acids, Alpha-Hydroxy Acids, and Peptides Including Phytochelatins." Funded; Project Coordinator: Prof. Giovanni Predieri.

ADDITIONAL FUNDING

2020 and 2021: Funding for doctoral mobility through two Short Term Scientific Missions within the COST Action CA18202 - Network for Equilibria and Chemical Thermodynamics Advanced Research (NECTAR). NECTAR STSMs.
2005 and 2011: Funding by CIRCMSB (Interuniversity Consortium for Research on Metals in Biological Systems) for 12-month fellowships awarded to Dr. Manuela Bersellini ("De Novo Design of Metallopeptides for Artificial Copper Proteins," 2011) and Dr. Luca Ferretti ("Synthesis, Structural Characterization, and Solution Thermodynamic Study of Phytochelatin Complexes with Biologically Relevant Metal Ions," 2005), for which I was responsible.
2001-2017: Local funding from the University of Parma (FIL).

INVITED LECTURES AND SEMINARS

INVITED SEMINARS

2017, May 22, Department of Chemistry - University of Michigan: "Metallacrowns-based innovative materials and supramolecular devices."
2017, May 16, Department of Chemistry - University of Zurich: "Toward artificial biomolecules through De novo Metallopeptide Design."
2016, May 26, Department of Chemistry and Industrial Chemistry, University of Pisa: "Metallacrowns-based innovative materials and supramolecular devices."
2016, February 24, Department of Chemistry, University of Padua: "Metallacrowns-based innovative materials and supramolecular devices."
2015, May 5, Department of Chemical and Pharmaceutical Sciences, University of Ferrara: "De novo Metalloprotein Design: where Coordination Chemistry meets Molecular Biology."
2009, April 21, Department of Biotechnology and Biosciences, University of Milano Bicocca: "Self-assembly of copper(II) metallacrowns: a thermodynamic approach."

INVITED PRESENTATIONS AT CONFERENCES OR SYMPOSIA

2024, "Designing SpyTag peptides: on the way to artificial copper enzymes," MBP 2024 2nd International Conference on Metal-Binding Peptides, June 10-12, Toulouse, France.
2022, "Designing the SpyCatcher/SpyTag construct into a new artificial metalloprotein," Artificial Proteins in the 21st Century: Designed (metallo)proteins, April 6-8, Marseille, France.
2022, "Copper binding at His-His sites of model peptides: implications on oxidase activity," MBP 2022 International Conference on Metal-Binding Peptides, July 5-8, Nancy, France.
2019, "Copper(I) and copper(II) binding to R1 and R3 fragments of tau protein," ICBIC-19 19th International Conference on Biological Inorganic Chemistry, August 11-16, Interlaken, Switzerland.
2017, "NMR features of paramagnetic metallacrowns and metallacryptates containing Ln(III) ions," 1st International Symposium on Metallacrowns and Metallacryptates, September 28-29, Parma, Italy.
2015, "Forever young: the nice story of Metallacrowns from the perspective of a solution chemist," XIII International Symposium on Inorganic Biochemistry, September 1-6, Karpacz, Poland.
2012, "Designing a functional type 2 copper center with nitrite reductase activity within α-helical coiled coils," Final Symposium of the Blaise Pascal Chair of Prof. Vincent L. Pecoraro, November 20, Université Paris Sud, Paris, France.
2011, "De novo designed Type 2 copper metallopeptide as a functional redox model of nitrite reductase," ArtZymes 2011 – Artificial Metalloenzymes Symposium, September 25-28, Marseille, France.
2007, "Copper(II) 12-metallacrown-4 of α-, β- and γ-aminohydroxamic acids: a comparative study in aqueous solution," XVIII ISMEC - Italian-Spanish Congress on the Thermodynamics of Metal Complexes, June 5-9, Cagliari, Italy.

CONFERENCE ORGANIZATION AND EVALUATION COMMITTEES

EVENT ORGANIZATION

2020-2023: Member of the Scientific Committee for meetings of COST Action CA18202 - NECTAR (Network for Equilibria and Chemical Thermodynamics Advanced Research) held in Belgrade (March 5-6, 2020), Lisbon (August 25-27, 2021), Ljubljana (August 24-26, 2022), and Milazzo (February 26-27, 2024).
2017: Organizer and Chairman, 1st International Symposium on Metallacrowns and Metallacryptates, Parma, September 28-29.
2014: Member of the Scientific Committee, “CRISTALLI!” exhibition, October 11 – November 30, Palazzo della Pilotta, Parma, Italy.
2013: Member of the Organizing Committee, XLI National Congress of the Italian Chemical Society’s Division of Inorganic Chemistry, September 3-6, Parma.
2010: Member of the Scientific Committee and Organizer, X Chemistry Day of the Italian Chemical Society, Emilia-Romagna Section, Parma, November 26.
2009: Member of the Organizing Committee, IX National Congress on Supramolecular Chemistry, Parma, Italy, September 6-9.
2007: Member of the Organizing Committee, XVIII ISMEC - Italian-Spanish Congress on the Thermodynamics of Metal Complexes, Cagliari, Italy, June 5-9.
2006: Member of the Scientific Committee and Organizer, VI Chemistry Day of the Italian Chemical Society, Emilia-Romagna Section, Parma, November 24.

EVALUATION COMMITTEES

2015-2024: Member of the Poster Award Evaluation Committee at international conferences (XIII International Symposium on Inorganic Biochemistry, Karpacz, Poland, 2015; MBP 2022 1st International Conference on Metal-Binding Peptides, Nancy, France, 2022; MBP 2024 2nd International Conference on Metal-Binding Peptides, Toulouse, France, 2024).
2008-2009: Member of the Selection Committee for Researcher positions at the Universities of Bologna (2008), Pavia (2009), and Milano-Bicocca (2021).
2011-2024: Member of PhD defense committees, PhD thesis evaluator, and reviewer of doctoral candidates for entrance examinations at the Universities of Granada (Spain), Warsaw (Poland), Marseille (France), Pavia, Modena and Reggio Emilia, and Camerino.
2003-2010: Member of the Evaluation Committee for annual doctoral student awards of the Emilia-Romagna section of the Italian Chemical Society.

REVIEWER ACTIVITY

Since 2001, I have served as a reviewer for various international scientific journals, including ACS Inorganic Chemistry, RSC Dalton Transactions, Journal of Inorganic Biochemistry, Organic and Biomolecular Chemistry, Chemistry - A European Journal, Inorganica Chimica Acta, and Polyhedron.

AFFILIATION WITH SCIENTIFIC SOCIETIES
• 2019-2024: Member of the Management Committee (Italian delegate) and Grant Awarding Coordinator for COST Action CA18202 - Network for Equilibria and Chemical Thermodynamics Advanced Research (NECTAR) (link)
• 2004-2006: Member of the National Council of the Young Chemists Group of the SCI (Italian Chemical Society), elected delegate of the Inorganic Chemistry Division - Council Treasurer.
• 2003-2011: Member of the Council of the Emilia Romagna regional section of the Italian Chemical Society. Secretary of the Emilia Romagna section from 2003 to 2005 and Treasurer.
• 2003-2024: Member of CIRCMSB (Interuniversity Research Consortium on Metal Chemistry in Biological Systems).
• 2001-present: Member of the European Group of Thermodynamics of Metal Complexes (link).
TEACHING ACTIVITIES
Since 2002, I have been teaching General and Inorganic Chemistry Laboratory for the Chemistry Degree Program at the University of Parma (from 2002 to 2015 and from 2020 to present). Since 2019, I have also taught Inorganic Systems in Biology in the Master’s program in Biomolecular, Genomic, and Cellular Sciences. Between 2018 and 2020, I taught General and Organic Chemistry (General and Inorganic Chemistry module) for the Bachelor’s program in Animal Science and Animal Production Technologies, as well as the Chemistry module in Biochemical Propaedeutics for the single-cycle Veterinary Medicine program. Previously, from 2002 to 2010, I taught General and Inorganic Chemistry and Laboratory, Inorganic Chemistry Laboratory, and Physical Methods in Bioinorganic and Inorganic Chemistry in both Bachelor’s and Master’s programs in Chemistry, Biological Sciences, and Natural Sciences. In 2017, I taught a Chemistry Databases course for the Master’s program in Chemistry. Additionally, in 2006, I was an instructor for the "Instrumental Chemical Analysis" course for high school teachers, held at ITIS “Nobili” in Reggio Emilia. A full list of my teaching assignments is detailed below.
Since 2002, I have supervised 48 Bachelor’s and Master’s theses in Chemistry, Industrial Chemistry, and Biomolecular, Genomic, and Cellular Sciences. I have also served as the advisor for three doctoral theses in Chemical Sciences and as co-supervisor for three others.
PhD Thesis Supervision
• Corrado Atzeri; "Supramolecular coordination complexes as building blocks for porous and magnetic materials"; University of Parma, 2016
• Vittoria Marzaroli; "Thriving metallacrowns: from structural description in solution to assembly of porous materials"; University of Parma, 2019
• Silvia Gentili; "Copper/histidine sites in designed peptides and artificial proteins"; University of Parma, 2022
University Teaching Responsibilities (All teaching duties were carried out at the University of Parma)
Academic Year 2002/03
• General and Inorganic Chemistry Laboratory - Bachelor’s in Biological Sciences (2 CFU).
• General and Inorganic Chemistry Laboratory - Bachelor’s in Natural Sciences (1 CFU).
Academic Year 2003/04
• General and Inorganic Chemistry - Bachelor’s in Natural Sciences (3 CFU).
• General and Inorganic Chemistry Laboratory - Bachelor’s in Ecological Biology (2 CFU).
Academic Year 2004/05
• General and Inorganic Chemistry Laboratory - Bachelor’s in Ecological Biology (2 CFU).
• Physical Methods in Bioinorganic Chemistry - Master’s in Chemistry (3 CFU).
Academic Year 2005/06
• General and Inorganic Chemistry Laboratory - Bachelor’s in Ecological Biology (2 CFU).
• Physical Methods in Bioinorganic Chemistry - Master’s in Chemistry (3 CFU).
Academic Year 2006/07
• General and Inorganic Chemistry - Bachelor’s in Natural Sciences (6 CFU).
• General and Inorganic Chemistry Laboratory - Bachelor’s in Ecological Biology (2 CFU).
• Physical Methods in Bioinorganic Chemistry - Master’s in Chemistry (3 CFU).
Academic Year 2007/08
• General Chemistry Laboratory - Bachelor’s in Ecological Biology (2 CFU).
• Inorganic Chemistry Laboratory - Bachelor’s in Chemistry (2 CFU).
• Physical Methods in Bioinorganic Chemistry - Master’s in Chemistry (3 CFU).
Academic Year 2008/09
• General and Inorganic Chemistry Laboratory - Bachelor’s in Chemical Sciences and Technology (4 CFU).
• General Chemistry Laboratory - Bachelor’s in Ecological Biology (2 CFU).
• Physical Methods in Bioinorganic Chemistry - Master’s in Chemistry (3 CFU).
Academic Year 2009/10
• General and Inorganic Chemistry Laboratory - Bachelor’s in Chemistry (4 CFU).
• Physical Methods in Inorganic Chemistry - Master’s in Chemistry (3 CFU).
• Global Climate Change - Master’s in Natural Sciences (1 CFU).
Academic Year 2010/11
• General and Inorganic Chemistry Laboratory - Bachelor’s in Chemistry (3 CFU).
Academic Year 2011/12
• General and Inorganic Chemistry Laboratory - Bachelor’s in Chemistry (6 CFU).
• Physical Methods in Inorganic Chemistry - Bachelor’s in Chemistry (3 CFU).
Academic Years 2012/13 to 2014/15
• General and Inorganic Chemistry Laboratory - Bachelor’s in Chemistry (6 CFU).
Academic Year 2016/17
• Chemistry Databases - Master’s in Chemistry (2 CFU).
Academic Year 2018/19
• Chemistry Module (Biochemical Propaedeutics course) - Five-year single-cycle Master’s in Veterinary Medicine (3 CFU).
• General and Inorganic Chemistry Module (General and Organic Chemistry course) - Bachelor’s in Animal Science and Animal Production Technologies (5 CFU).
• Inorganic Systems in Biology - Master’s in Biomolecular, Genomic, and Cellular Sciences (6 CFU).
Academic Year 2019/20
• Chemistry Module (Biochemical Propaedeutics course) - Five-year single-cycle Master’s in Veterinary Medicine (3 CFU).
• General and Inorganic Chemistry Module (General and Organic Chemistry course) - Bachelor’s in Animal Science and Animal Production Technologies (5 CFU).
• Inorganic Systems in Biology - Master’s in Biomolecular, Genomic, and Cellular Sciences (6 CFU).
Academic Year 2019/20 through 2024/25
• General and Inorganic Chemistry Laboratory - Bachelor’s in Chemistry (6 CFU).
• Inorganic Systems in Biology - Master’s in Biomolecular, Genomic, and Cellular Sciences (6 CFU).
Other Teaching Activities
• High school teachers’ course on "Instrumental Chemical Analysis" - Istituto Tecnico Industriale (ITIS "Leopoldo Nobili"), Reggio Emilia, 2006.

Institutional Activities
• 2019-2022: Member of the International Mobility Committee for the Department of Chemistry, Life Sciences, and Environmental Sustainability.
• Since 2018: Head of Tutoring Activities for the Chemistry area at the Department of Chemistry, Life Sciences, and Environmental Sustainability.
• 2017-present: Coordinator for the "OVERWORLD" university mobility projects for graduating students at the University of Michigan (Academic Years 2016/17 and 2017/18).
• 2015-2017: Co-coordinator of the School-Work Alternation program for the Department of Chemistry at the University of Parma.
• 2012-2018 and 2020-present: Member of the Teaching Committee for the Degree Programs in Chemistry and Industrial Chemistry.
• 2009-2018: Member of the Doctoral Board for the PhD in Chemical Sciences.
• 2002-2016: Member of the Faculty Council for the Degree Programs in Chemistry and Industrial Chemistry (2004-2016), Biology (2002-2009), and Natural Sciences (2002-2004 and 2009/2010) at the University of Parma.
• 2002-2012: Member of the Faculty of Mathematical, Physical, and Natural Sciences at the University of Parma.
• 2002-present: Affiliate of the Department of General and Inorganic Chemistry, Analytical Chemistry, Physical Chemistry (until 2012), Department of Chemistry (until 2016), and Department of Chemistry, Life Sciences, and Environmental Sustainability (since 2017).
OUTREACH ACTIVITIES
Since 2002, I have actively participated in organizing and conducting numerous public outreach events to promote Chemistry as a scientific field, along with events for the Italian Chemical Society at both the regional and national levels. Key events include:
• 2024: “Chemistry in Color” outreach project. Sessions for second-year students at “L. Da Vinci” Middle School, S. Ilario d’Enza, Reggio Emilia.
• 2014: “CRYSTALS!” Exhibition, October 11 – November 30, Salone delle Scuderie, Palazzo della Pilotta, Parma, Italy.
• 2009; 2013-2018; 2020-2023: "Researchers' Night" at the University of Parma, organizer of thematic rooms.
• 2011: Outreach event "Chemistry Between Us" at the University of Parma, October 21-22.
• 2003-2011: Organizer of the local "Chemistry Games" competition for high school students, serving as a qualifier for the National and International Chemistry Olympiads.

PUBLICATIONS (PAPERS) ON PEER REVIEWED JOURNALS

(From the most recent)

1. Cerveri, A.; Scarica, G.; Sparascio, S.; Hoch, M.; Chiminelli, M.; Tegoni, M.; Protti, S.; Maestri, G. Boosting Energy-Transfer Processes via Dispersion Interactions. Chem. Eur. J. 2024, 30 (15), e202304010. https://doi.org/10.1002/chem.202304010.
2. Albanese, V.; Roccatello, C.; Pacifico, S.; Guerrini, R.; Preti, D.; Gentili, S.; Tegoni, M.; Remelli, M.; Bellotti, D.; Amico, J.; Gorgoni, G.; Cazzola, E. Bifunctional Octadentate Pseudopeptides as Zirconium-89 Chelators for Immuno-PET Applications. EJNMMI Radiopharm. Chem. 2024, 9 (1), 38. https://doi.org/10.1186/s41181-024-00263-1.
3. Miglioli, F.; Joel, S.; Tegoni, M.; Neira-Pelén, P.; Günther, S.; Carcelli, M.; Fisicaro, E.; Brancale, A.; Fernández-García, Y.; Rogolino, D. Inhibitory Interactions of the 2,3-Dihydro-6,7-Dihydroxy-1H-Isoindol-1-One Scaffold with Bunyavirales Cap-Snatching Endonucleases Expose Relevant Drug Design Features. Eur. J. Med. Chem. 2024, 272, 116467. https://doi.org/10.1016/j.ejmech.2024.116467.
4. Zavaroni, A.; Riva, E.; Borghesani, V.; Donati, G.; Santoro, F.; D’Amore, V. M.; Tegoni, M.; Pelosi, G.; Buschini, A.; Rogolino, D.; Carcelli, M. Synthesis and Preliminary Studies for In Vitro Biological Activity of Two New Water-Soluble Bis(Thio)Carbohydrazones and Their Copper(II) and Zinc(II) Complexes. Int. J. Mol. Sci. 2024, 25 (19), 10831. https://doi.org/10.3390/ijms251910831.
5. Melegari, M.; Marzaroli, V.; Polisicchio, R.; Seletti, D.; Marchiò, L.; Pecoraro, V. L.; Tegoni, M. Insights on the Structure in Solution of Paramagnetic LnIII /GaIII 12-Metallacrown-4 Complexes Using 1D 1H NMR and Model Structures. Inorg. Chem. 2023, 62 (27), 10645–10654. https://doi.org/10.1021/acs.inorgchem.3c00983.
6. Carcelli, M.; Compari, C.; Fisicaro, E.; Incerti, M.; Miglioli, F.; Peracchia, E.; Pertinhez, T. A.; Rogolino, D.; Ronda, N.; Gentili, S.; Tegoni, M. A Potentiometric and Spectrofluorimetric Approach to Unravel Inhibitory Effects of Semi- and Thiosemicarbazones on Mushroom Tyrosinase Activity. J. Biol. Inorg. Chem. 2023, 28 (1), 17–27. https://doi.org/10.1007/s00775-022-01976-x.
7. Oumarou Amadou, A.; Cera, M.; Trudu, S.; Piredda, M.; Cara, S.; De Gaudenzi, G. Pietro; Matharu, A. S.; Marchiò, L.; Tegoni, M.; Muntoni, A.; De Gioannis, G.; Serpe, A. A Comparison among Bio-Derived Acids as Selective Eco-Friendly Leaching Agents for Cobalt: The Case Study of Hard-Metal Waste Enhancement. Front. Environ. Chem. 2023, 4, 1216245. https://doi.org/10.3389/fenvc.2023.1216245.
8. Melegari, M.; Tegoni, M. Aspects of NMR Characterization of Metallacrowns. In Advances in Metallacrown Chemistry; 2022; pp 37–76. https://doi.org/10.1007/978-3-031-08576-5_2.
9. Falco, A.; Neri, M.; Melegari, M.; Baraldi, L.; Bonfant, G.; Tegoni, M.; Serpe, A.; Marchiò, L. Semirigid Ligands Enhance Different Coordination Behavior of Nd and Dy Relevant to Their Separation and Recovery in a Non-Aqueous Environment. Inorg. Chem. 2022, 61 (40), 16110–16121. https://doi.org/10.1021/acs.inorgchem.2c02619.
10. Salerno, E. V.; Foley, C. M.; Marzaroli, V.; Schneider, B. L.; Sharin, M. D.; Kampf, J. W.; Marchiò, L.; Zeller, M.; Guillot, R.; Mallah, T.; Tegoni, M.; Pecoraro, V. L.; Zaleski, C. M. Unique Dimerization Topology and Countercation Binding Modes in 12‐Metallacrown‐4 Compounds. Eur. J. Inorg. Chem. 2022, e202200439. https://doi.org/10.1002/ejic.202200439.
11. Bacchella, C.; Gentili, S.; Mozzi, S. I.; Monzani, E.; Casella, L.; Tegoni, M.; Dell’Acqua, S. Role of the Cysteine in R3 Tau Peptide in Copper Binding and Reactivity. Int. J. Mol. Sci. 2022, 23 (18), 10726. https://doi.org/10.3390/ijms231810726.
12. Sgarlata, C.; Schneider, B. L.; Zito, V.; Migliore, R.; Tegoni, M.; Pecoraro, V. L.; Arena, G. Lanthanide Identity Governs Guest‐Induced Dimerization in LnIII [15‐MCN(L‐pheHA)‐5])3+ Metallacrowns. Chem. Eur. J. 2021, 27 (70), 17669–17675. https://doi.org/10.1002/chem.202103263.
13. Bergamonti, L.; Gentili, S.; Acquotti, D.; Tegoni, M.; Lottici, P. P.; Graiff, C. Toxic Metal Sequential Sequestration in Water Using New Amido-Aminoacid Ligand as a Model for the Interaction with Polyamidoamines. J. Hazard. Mater. 2021, 410, 124585. https://doi.org/10.1016/j.jhazmat.2020.124585.
14. Perinelli, M.; Tegoni, M.; Freisinger, E. Different Behavior of the Histidine Residue toward Cadmium and Zinc in a Cadmium-Specific Metallothionein from an Aquatic Fungus. Inorg. Chem. 2020, 59 (23), 16988–16997. https://doi.org/10.1021/acs.inorgchem.0c02171.
15. Carcelli, M.; Tegoni, M.; Bartoli, J.; Marzano, C.; Pelosi, G.; Salvalaio, M.; Rogolino, D.; Gandin, V. In Vitro and in Vivo Anticancer Activity of Tridentate Thiosemicarbazone Copper Complexes: Unravelling an Unexplored Pharmacological Target. Eur. J. Med. Chem. 2020, 194, 112266. https://doi.org/10.1016/j.ejmech.2020.112266.
16. Bacchella, C.; Gentili, S.; Bellotti, D.; Quartieri, E.; Draghi, S.; Baratto, M. C.; Remelli, M.; Valensin, D.; Monzani, E.; Nicolis, S.; Casella, L.; Tegoni, M.; Dell’Acqua, S. Binding and Reactivity of Copper to R 1 and R 3 Fragments of Tau Protein. Inorg. Chem. 2020, 59 (1), 274–286. https://doi.org/10.1021/acs.inorgchem.9b02266.
17. Perinelli, M.; Guerrini, R.; Albanese, V.; Marchetti, N.; Bellotti, D.; Gentili, S.; Tegoni, M.; Remelli, M. Cu(II) Coordination to His-Containing Linear Peptides and Related Branched Ones: Equalities and Diversities. J. Inorg. Biochem. 2020, 205, 110980. https://doi.org/10.1016/j.jinorgbio.2019.110980.
18. Marzaroli, V.; Spigolon, G.; Lococciolo, G.; Quaretti, M.; Salviati, C.; Kampf, J. W.; Licini, G.; Marchiò, L.; Pecoraro, V. L.; Tegoni, M. Three-Dimensional Porous Architectures Based on MnII/III Three-Blade Paddle Wheel Metallacryptates. Cryst. Growth Des. 2019, 19 (3), 1954–1964. https://doi.org/10.1021/acs.cgd.8b01921.
19. Bergamonti, L.; Graiff, C.; Tegoni, M.; Predieri, G.; Elviri, L.; Palanti, S.; Paris, C.; Cappelletto, E.; Di Maggio, R.; Lottici, P. P. Facile Preparation of Functionalized Poly(Amidoamine)s with Biocidal Activity on Wood Substrates. Eur. Polym. J. 2019, 116, 232–241.
20. Quaretti, M.; Porchia, M.; Tisato, F.; Trapananti, A.; Aquilanti, G.; Damjanović, M.; Marchiò, L.; Giorgetti, M.; Tegoni, M. Thermodynamic Stability and Structure in Aqueous Solution of the [Cu(PTA)4]+ Complex (PTA = Aminophosphine 1,3,5 triaza 7 phosphaadamantane). J. Inorg. Biochem. 2018, 188, 50–61. https://doi.org/10.1016/j.jinorgbio.2018.08.008.
21. Atzeri, C.; Marzaroli, V.; Quaretti, M.; Travis, J. R.; Di Bari, L.; Zaleski, C. M.; Tegoni, M. Elucidation of 1H NMR Paramagnetic Features of Heterotrimetallic Lanthanide(III)/Manganese(III) 12-MC-4 Complexes. Inorg. Chem. 2017, 56 (14), 8257–8269. https://doi.org/10.1021/acs.inorgchem.7b00970.
22. Rogolino, D.; Cavazzoni, A.; Gatti, A.; Tegoni, M.; Pelosi, G.; Verdolino, V.; Fumarola, C.; Cretella, D.; Petronini, P. G.; Carcelli, M. Anti-Proliferative Effects of Copper(II) Complexes with Hydroxyquinoline-Thiosemicarbazone Ligands. Eur. J. Med. Chem. 2017, 128, 140–153. https://doi.org/10.1016/j.ejmech.2017.01.031.
23. Bergamonti, L.; Graiff, C.; Tegoni, M.; Predieri, G.; Bellot-Gurlet, L.; Lottici, P. P. P. P. Raman and NMR Kinetics Study of the Formation of Amidoamines Containing N-Hydroxyethyl Groups and Investigations on Their Cu(II) Complexes in Water. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2017, 171, 515–524. https://doi.org/10.1016/j.saa.2016.07.041.
24. Tisato, F.; Marzano, C.; Peruzzo, V.; Tegoni, M.; Giorgetti, M.; Damjanovic, M.; Trapananti, A.; Bagno, A.; Santini, C.; Pellei, M.; Porchia, M.; Gandin, V. Insights into the Cytotoxic Activity of the Phosphane Copper(I) Complex [Cu(Thp)4][PF6]. J. Inorg. Biochem. 2016, 165, 80–91. https://doi.org/10.1016/j.jinorgbio.2016.07.007.
25. Lamberts, K.; Tegoni, M.; Jiang, X.; Kou, H.-Z.; Englert, U. Silver Complexation by Metallacryptates. Dalton Trans. 2016, 45 (1), 284–295. https://doi.org/10.1039/C5DT03749B.
26. Atzeri, C.; Marchiò, L.; Chow, C. Y.; Kampf, J. W.; Pecoraro, V. L.; Tegoni, M. Design of 2D Porous Coordination Polymers Based on Metallacrown Units. Chem. Eur. J. 2016, 22 (19), 6482–6486. https://doi.org/10.1002/chem.201600562.
27. Selva Bonino, V. E.; Tegoni, M.; Mucchino, C.; Predieri, G.; Casoli, A. Model Study of the Constituents of Wall Painting Degradation Patinas: The Effect of the Treatment with Chelating Agents on the Solubility of the Calcium Salts. Microchem. J. 2015, 118, 62–68. https://doi.org/10.1016/j.microc.2014.08.001.
28. Marchiò, L.; Marchetti, N.; Atzeri, C.; Borghesani, V.; Remelli, M.; Tegoni, M. The Peculiar Behavior of Picha in the Formation of Metallacrown Complexes with Cu(II), Ni(II) and Zn(II) in Aqueous Solution. Dalton Trans. 2015, 44 (7), 3237–3250. https://doi.org/10.1039/C4DT03264K.
29. Yu, F.; Cangelosi, V. M.; Zastrow, M. L.; Tegoni, M.; Plegaria, J. S.; Tebo, A. G.; Mocny, C. S.; Ruckthong, L.; Qayyum, H.; Pecoraro, V. L. Protein Design: Toward Functional Metalloenzymes. Chem. Rev. 2014, 114 (7), 3495–3578. https://doi.org/10.1021/cr400458x.
30. Beccia, M. R.; García, B.; García-Tojal, J.; Leal, J. M.; Secco, F.; Tegoni, M. The Mechanism of the Cu2+[12-MCCu(Alaha)-4] Metallacrown Formation and Lanthanum(III) Encapsulation. Dalton Trans. 2014, 43 (24), 9271–9282. https://doi.org/10.1039/C4DT00557K.
31. Tegoni, M.; Valensin, D.; Toso, L.; Remelli, M. Copper Chelators: Chemical Properties and Bio-Medical Applications. Curr. Med. Chem. 2014, 21 (33), 3785–3818. https://doi.org/10.2174/0929867321666140601161939.
32. Tegoni, M. De Novo Designed Copper α-Helical Peptides: From Design to Function. Eur. J. Inorg. Chem. 2014, 2014 (13), 2177–2193. https://doi.org/10.1002/ejic.201400057.
33. Remelli, M.; Bacco, D.; Dallavalle, F.; Lazzari, E.; Marchetti, N.; Tegoni, M. Stoichiometric Diversity of Ni(Ii) Metallacrowns with β-Alaninehydroxamic Acid in Aqueous Solution. Dalton Trans. 2013, 42 (22), 8018–8025. https://doi.org/10.1039/c3dt50370d.
34. Tegoni, M.; Remelli, M. Metallacrowns of Copper(II) and Aminohydroxamates: Thermodynamics of Self Assembly and Host–Guest Equilibria. Coord. Chem. Rev. 2012, 256 (1–2), 289–315. https://doi.org/10.1016/j.ccr.2011.06.007.
35. Tardito, S.; Barilli, A.; Bassanetti, I.; Tegoni, M.; Bussolati, O.; Franchi-Gazzola, R.; Mucchino, C.; Marchiò, L. Copper-Dependent Cytotoxicity of 8-Hydroxyquinoline Derivatives Correlates with Their Hydrophobicity and Does Not Require Caspase Activation. J. Med. Chem. 2012, 55 (23), 10448–10459. https://doi.org/10.1021/jm301053a.
36. Lim, C.-S.; Tegoni, M.; Jakusch, T.; Kampf, J. W.; Pecoraro, V. L.; Jackush, T.; Kampf, J. W.; Pecoraro, V. L. Clarifying the Mechanism of Cation Exchange in Ca(II)[15-MC Cu(II)Ligand-5] Complexes. Inorg. Chem. 2012, 51 (21), 11533–11540. https://doi.org/10.1021/ic3013798.
37. Tegoni, M.; Yu, F.; Bersellini, M.; Penner-Hahn, J. E.; Pecoraro, V. L. Designing a Functional Type 2 Copper Center That Has Nitrite Reductase Activity within α-Helical Coiled Coils. Proc. Natl. Acad. Sci. U. S. A. 2012, 109 (52), 21234–21239. https://doi.org/10.1073/pnas.1212893110.
38. Asti, M.; Tegoni, M.; Farioli, D.; Iori, M.; Guidotti, C.; Cutler, C. S.; Mayer, P.; Versari, A.; Salvo, D. Influence of Cations on the Complexation Yield of DOTATATE with Yttrium and Lutetium: A Perspective Study for Enhancing the 90Y and 177Lu Labeling Conditions. Nucl. Med. Biol. 2012, 39 (4), 509–517. https://doi.org/10.1016/j.nucmedbio.2011.10.015.
39. Aquilanti, G.; Giorgetti, M.; Minicucci, M.; Papini, G.; Pellei, M.; Tegoni, M.; Trasatti, A.; Santini, C. A Study on the Coordinative Versatility of New N,S-Donor Macrocyclic Ligands: XAFS, and Cu2+ Complexation Thermodynamics in Solution. Dalton Trans. 2011, 40 (12), 2764–2777. https://doi.org/10.1039/c0dt01401j.
40. Tardito, S.; Bassanetti, I.; Bignardi, C.; Elviri, L.; Tegoni, M.; Mucchino, C.; Bussolati, O.; Franchi-Gazzola, R.; Marchiò, L. Copper Binding Agents Acting as Copper Ionophores Lead to Caspase Inhibition and Paraptotic Cell Death in Human Cancer Cells. J. Am. Chem. Soc. 2011, 133 (16), 6235–6242. https://doi.org/10.1021/ja109413c.
41. Bacco, D.; Bertolasi, V.; Dallavalle, F.; Galliera, L.; Marchetti, N.; Marchiò, L.; Remelli, M.; Tegoni, M. Metallacrowns of Ni(II) with α-Aminohydroxamic Acids in Aqueous Solution: Beyond a 12-MC-4, an Unexpected (Vacant?) 15-MC-5. Dalton Trans. 2011, 40 (11), 2491–2501. https://doi.org/10.1039/c0dt00832j.
42. Tisato, F.; Refosco, F.; Porchia, M.; Tegoni, M.; Gandin, V.; Marzano, C.; Pellei, M.; Papini, G.; Lucato, L.; Seraglia, R.; Traldi, P. The Relationship between the Electrospray Ionization Behaviour and Biological Activity of Some Phosphino Cu(I) Complexes. Rapid Commun. Mass Spectrom. 2010, 24 (11), 1610–1616. https://doi.org/10.1002/rcm.4553.
43. Dallavalle, F.; Remelli, M.; Sansone, F.; Bacco, D.; Tegoni, M. Thermodynamics of Self-Assembly of Copper(II) 15-Metallacrown-5 of Eu(III) or Gd(III) with (S)-Alpha-Alaninehydroxamic Acid in Aqueous Solution. Inorg. Chem. 2010, 49 (4), 1761–1772. https://doi.org/10.1021/ic902146d.
44. Tegoni, M.; Furlotti, M.; Tropiano, M.; Lim, C. S.; Pecoraro, V. L. Thermodynamics of Core Metal Replacement and Self-Assembly of Ca2+ 15-Metallacrown-5. Inorg. Chem. 2010, 49 (11), 5190–5201. https://doi.org/10.1021/ic100315u.
45. Delferro, M.; Marchiò, L.; Tegoni, M.; Tardito, S.; Franchi-Gazzola, R.; Lanfranchi, M. Synthesis, Structural Characterisation and Solution Chemistry of Ruthenium(III) Triazole-Thiadiazine Complexes. Dalton Trans. 2009, No. 19, 3766–3773. https://doi.org/10.1039/b823271g.
46. Delferro, M.; Tegoni, M.; Verdolino, V.; Cauzzi, D.; Graiff, C.; Tiripicchio, A. Oxidative Addition of Iodomethane to Charge-Tuned Rhodium(I) Complexes. Organometallics 2009, 28 (7), 2062–2071. https://doi.org/10.1021/om8012037.
47. Tegoni, M.; Tropiano, M.; Marchiò, L. Thermodynamics of Binding of Carboxylates to Amphiphilic Eu3+/Cu2+ Metallacrown. Dalton Trans. 2009, 6705–6708. https://doi.org/10.1039/b911512a.
48. Delferro, M.; Cauzzi, D.; Pattacini, R.; Tegoni, M.; Graiff, C.; Tiripicchio, A. A Study on the Coordinative Versatility of the Zwitterionic S,N,S Ligand EtNHC(S)Ph2P=NPPh2C(S)NEt in Its Anionic, Neutral and Cationic Forms - Determination of Absolute pKa Values in CH2Cl2 of RhI Complexes. Eur. J. Inorg. Chem. 2008, 2008 (14), 2302–2312. https://doi.org/10.1002/ejic.200800075.
49. Gennari, M.; Tegoni, M.; Lanfranchi, M.; Pellinghelli, M. A.; Giannetto, M.; Marchiò, L. CuI Complexes with N,N’,S,S’ Scorpionate Ligands: Evidence for Dimer-Monomer Equilibria. Inorg. Chem. 2008, 47 (6), 2223–2232. https://doi.org/10.1021/ic702108x.
50. Tegoni, M.; Remelli, M.; Bacco, D.; Marchiò, L.; Dallavalle, F. Copper(II) 12-Metallacrown-4 Complexes of Alpha-, Beta- and Gamma-Aminohydroxamic Acids: A Comparative Thermodynamic Study in Aqueous Solution. Dalton Trans. 2008, No. 20, 2693–2701. https://doi.org/10.1039/b718765c.
51. Tardito, S.; Bussolati, O.; Maffini, M.; Tegoni, M.; Giannetto, M.; Dall’asta, V.; Franchi-Gazzola, R.; Lanfranchi, M.; Pellinghelli, M. A.; Mucchino, C.; Mori, G.; Marchiò, L. Thioamido Coordination in a Thioxo-1,2,4-Triazole Copper(II) Complex Enhances Nonapoptotic Programmed Cell Death Associated with Copper Accumulation and Oxidative Stress in Human Cancer Cells. J. Med. Chem. 2007, 50 (8), 1916–1924. https://doi.org/10.1021/jm061174f.
52. Tegoni, M.; Ferretti, L.; Sansone, F.; Remelli, M.; Bertolasi, V.; Dallavalle, F. Synthesis, Solution Thermodynamics, and X-Ray Study of CuII[12]Metallacrown-4 with GABA Hydroxamic Acid: An Unprecedented Crystal Structure of a [12]MC-4 with a Gamma-Aminohydroxamate. Chem. Eur. J. 2007, 13 (4), 1300–1308. https://doi.org/10.1002/chem.200601035.
53. Gennari, M.; Tegoni, M.; Lanfranchi, M.; Pellinghelli, M. A.; Marchio, L. A New Chiral N,N’,O-Donor Heteroscorpionate Ligand. Structures of Ni2+, Cu2+, Zn2+ Complexes and Study of Solution Equilibria by Means of 1H NMR/UV-Vis Titrations and EXSY NMR Spectroscopy. Inorg. Chem. 2007, 46 (8), 3367–3377. https://doi.org/10.1021/ic062228e.
54. Ferretti, L.; Elviri, L.; Pellinghelli, M. A.; Predieri, G.; Tegoni, M. Glutathione and N-Acetylcysteinylglycine: Protonation and Zn2+ Complexation. J. Inorg. Biochem. 2007, 101 (10), 1442–1456. https://doi.org/10.1016/j.jinorgbio.2007.06.020.
55. (55) Gennari, M.; Lanfranchi, M.; Marchio, L.; Pellinghelli, M. A.; Tegoni, M.; Cammi, R. Cu(I) Dinuclear Complexes with Tripodal Ligands vs Monodentate Donors: Triphenylphosphine, Thiourea, and Pyridine. A 1H NMR Titration Study. Inorg. Chem. 2006, 45 (8), 3456–3466.
56. Gaccioli, F.; Franchi-Gazzola, R.; Lanfranchi, M.; Marchiò, L.; Metta, G.; Pellinghelli, M. A.; Tardito, S.; Tegoni, M. Synthesis, Solution Equilibria and Antiproliferative Activity of Copper(II) Aminomethyltriazole and Aminomethylthioxotriazoline Complexes. J. Inorg. Biochem. 2005, 99 (8), 1573–1584. https://doi.org/10.1016/j.jinorgbio.2005.04.017.
57. Carcelli, M.; Ianelli, S.; Pelagatti, P.; Pelizzi, G.; Rogolino, D.; Solinas, C.; Tegoni, M. Synthesis and Characterization of New Lanthanide Complexes with Hexadentate Hydrazonic Ligands. Inorg.a Chim. Acta 2005, 358 (4), 903–911.
58. Predieri, G.; Elviri, L.; Tegoni, M.; Zagnoni, I.; Cinti, E.; Biagi, G.; Ferruzza, S.; Leonardi, G. Metal Chelates of 2-Hydroxy-4-Methylthiobutanoic Acid in Animal Feeding. Part 2: Further Characterizations, in Vitro and in Vivo Investigations. J. Inorg. Biochem. 2005, 99 (2), 627–636. https://doi.org/10.1016/j.jinorgbio.2004.11.011.
59. Ferloni, E.; Lanfranchi, M.; Marchiò, L.; Metta, G.; Pellinghelli, M. A.; Tegoni, M. Structure, Solution Equilibria and Magnetic Properties of Copper(II) Complexes with New Sulfurated Triazoline Derivatives of α-Amino Acids. Inorg.a Chim. Acta 2005, 358 (1), 147–160. https://doi.org/10.1016/j.ica.2004.08.016.
60. Tegoni, M.; Dallavalle, F.; Santos, M. A. Succinylhydroxamic Derivatives of α-Amino Acids as MMP Inhibitors. Study of Complex-Formation Equilibria with Cu2+, Ni2+ and Zn2+. J. Inorg. Biochem. 2004, 98 (2), 209–218. https://doi.org/10.1016/j.jinorgbio.2003.10.010.
61. Gennari, M.; Giannetto, M.; Lanfranchi, M.; Marchiò, L.; Pellinghelli, M. A.; Tegoni, M. Synthesis, Structure and Electrochemical Properties of a Nickel Complex with the Hydrotris[Thioxotriazolyl-3-(2-Pyridyl)]Borate Podand Ligand. Polyhedron 2004, 23 (10), 1829–1835. https://doi.org/10.1016/j.poly.2004.04.009.
62. Tegoni, M.; Dallavalle, F.; Belosi, B.; Remelli, M. Unexpected Formation of a Copper(II) 12-Metallacrown-4 with (S)-Glutamic-Gamma-Hydroxamic Acid: A Thermodynamic and Spectroscopic Study in Aqueous Solution. Dalton Trans. 2004, No. 9, 1329–1333. https://doi.org/10.1039/b316607d.
63. Del Rio, D.; Pellegrini, N.; Colombi, B.; Bianchi, M.; Serafini, M.; Torta, F.; Tegoni, M.; Musci, M.; Brighenti, F. Rapid Fluorimetric Method to Detect Total Plasma Malondialdehyde with Mild Derivatization Conditions. Clin. Chem. 2003, 49 (4), 690–692. https://doi.org/10.1373/49.4.690.
64. Bacchi, A.; Carcelli, M.; Pelizzi, C.; Pelizzi, G.; Pelagatti, P.; Rogolino, D.; Tegoni, M.; Viappiani, C. Synthesis and Spectroscopic and Structural Characterization of Two Novel Photoactivatable Ca2+ Compounds. Inorg. Chem. 2003, 42 (19), 5871–5879.
65. Predieri, G.; Tegoni, M.; Cinti, E.; Leonardi, G.; Ferruzza, S.; Bosi, P. Metal Chelates of 2-Hydroxy-4-Methylthiobutanoic Acid in Animal Feeding: Preliminary Investigations on Stability and Bioavailability. J. Inorg. Biochem. 2003, 95, 221–224.
66. Careri, M.; Dallavalle, F.; Tegoni, M.; Zagnoni, I. Pentacopper(II) 12-Metallacrown-4 Complexes with α- and β-Aminohydroxamic Acids in Aqueous Solution: A Reinvestigation. J. Inorg. Biochem. 2003, 93 (3–4), 174–180. https://doi.org/10.1016/S0162-0134(02)00570-6.
67. Santos, M. A.; Marques, S.; Gil, M.; Tegoni, M.; Scozzafava, A.; Supuran, C. T. Protease Inhibitors: Synthesis of Bacterial Collagenase and Matrix Metalloproteinase Inhibitors Incorporating Succinyl Hydroxamate and Iminodiacetic Acid Hydroxamate Moieties. J. Enzyme Inhib. Med. Chem. 2003, 18 (3), 233–242. https://doi.org/10.1080/1475636031000081134.
68. Dallavalle, F.; Gaccioli, F.; Franchi-Gazzola, R.; Lanfranchi, M.; Marchiò, L.; Pellinghelli, M. A.; Tegoni, M. Synthesis, Molecular Structure, Solution Equilibrium, and Antiproliferative Activity of Thioxotriazoline and Thioxotriazole Complexes of Copper(II) and Palladium(II). J. Inorg. Biochem. 2002, 92 (2), 95–104. https://doi.org/10.1016/S0162-0134(02)00545-7.
69. Tegoni, M. Metal Complexes of α-Amino Acid Derivates: Studies in Solution and in the Solid State. Acta Nat. l’Ateneo Parm. 2002, 38 (1), 79–83.
70. Dallavalle, F.; Tegoni, M. Speciation and Structure of Copper(II) Complexes with (S)-Phenylalanine- and (S)-Tryptophanhydroxamic Acids in Methanol/Water Solution: A Combined Potentiometric, Spectrophotometric, CD and ESI-MS Study. Polyhedron 2001, 20, 2697–2704. https://doi.org/10.1016/S0277-5387(01)00886-5
71. Dallavalle, F.; Folesani, G.; Sabatini, A.; Tegoni, M.; Vacca, A. Formation Equilibria of Ternary Complexes of Copper(II) with (S)-Tryptophanhydroxamic Acid and Both D- and L-Amino Acids in Aqueous Solution. Polyhedron 2001, 20 (1–2), 103–109. https://doi.org/10.1016/S0277-5387(00)00597-0.
72. Cingi, M. B.; Lanfranchi, M.; Pellinghelli, M. A.; Tegoni, M. Synthesis, Spectroscopic and Structural Characterization of New Ru(II) and Ru(III) Complexes Containing Triazole- and Thiadiazole-Type Ligands. Eur. J. Inorg. Chem. 2000, No. 4, 703–711. https://doi.org/10.1002/(sici)1099-0682(200004)2000:4<703::aid-ejic703>3.0.co;2-e

ARTICLES ON JOURNALS AND NEWSPAPERS

2022, 18 luglio “Pnrr: due milioni di euro all'ateneo per produrre idrogeno in batteri fotosintetici”, La Repubblica, Parma (Comunicato stampa)
2017, luglio. “Verso nuove frontiere delle scienze chimiche - Materiali innovativi e dispositivi basati sui Metallacrowns”, Platinum – Aziende e Protagonisti (allegato al Sole24Ore), Pag. 82 (Intervista).
2017, Casella, L.; Bubacco, L.; Valensin, D.; Tegoni, M. “Metal Ions, Dopamine and Oxidative Stress in Parkinson's Disease”, Impact, 2017, 6, pp. 9-11 (Intervista).
2016, 22 marzo “Metallacrowns, Progetto bilaterale Italia-USA” Gazzetta di Parma, pag. 25 (Comunicato stampa).
2014, 16 settembre “Molecole funzionali, la via del futuro per le tecnologie”, Gazzetta di Parma, pag. 26 (Comunicato stampa).
2013, 28 aprile. “Da bimbo amava i libri, ora è uno scienziato”. Gazzetta di Reggio, pag. 15 (Intervista).
2013, “Proteine artificiali per le sfide del futuro”, Gazzetta di Parma, pag. 34 (Intervista).

PATENTS

1. Santos Maria Amelia Loureiro D.; Marques Sergio Manuel; Gil Marco Antonio Dias De Sous; Tegoni Matteo; Chaves Silvia; Set of medicinal metal enzyme high capacity inhibitors comprises succinic and iminodiacetic acids giving high zinc and nickel ion complexing capacity. 103003 04.08.2003 PT

ORAL COMMUNICATIONS AT CONFERENCES

1. F. Dallavalle, M. Tegoni; Equilibria of copper(II) with α-aminohydroxamic acids in aqueous and aqueous/methanolic solution: a possible ambiguity dinuclear/pentanuclear species; ISMEC 2001 – XII Italian – Spanish Congress on Thermodynamic of Metal Complexes - Parma, 6-9 giugno 2001.
2. F. Dallavalle, M. Tegoni; Pentanuclear copper(II) complexes of α- and β-aminohydroxamic acids in aqueous solution; SIMEC 02– XIII Spanish - Italian Congress on the Thermodynamic of Metal Complexes – Santiago de Compostela, Spain, 2-6 giugno 2002.
3. F. Dallavalle, M. Lanfranchi, L. Marchiò, M.A. Pellinghelli, M. Tegoni; Synthesis and solution equilibria of sulfurated triazoline derivatives and their copper(II) complexes as new antiproliferative agents; 2nd Workshop on Pharmaco-Bio-Metallics. Siena, 29 novembre – 1 dicembre 2002.
4. F. Dallavalle, M. Tegoni, M. Remelli; Solution equilibria of copper(II) 15-metallacrown-5 complexes of (S)-α-alaninehydroxamic acid with lanthanides(III); SIMEC 2004– XV Spanish - Italian Congress on Thermodynamic of Metal Complexes – Huelva, Spain, 23-25 giugno 2004.
5. F. Dallavalle, M. Remelli, F. Sansone, M. Tegoni, G. Zarazaga; Formation equilibria of 15-metallacrown-5 of Eu3+ and Gd3+ with Cu2+ and (S)-α-alaninehydroxamic acid in aqueous solution; VII Congresso Nazionale di Chimica Supramolecolare, Firenze, Italy, 4-7 settembre 2005.
6. F. Dallavalle, L. Ferretti, M. Remelli, F. Sansone, M. Tegoni; Thermodynamics of copper(II)/GABA hydroxamate system in aqueous solution; XVI ISMEC - Italian-Spanish congress on the thermodynamics of metal complexes. Udine, 21-25 giugno 2005.
7. M. Tegoni, L. Ferretti, L. Elviri, M.A. Pellinghelli, G. Predieri; Phytochelatins and their model ligands: synthesis and study of metal chelating properties; XVII SIMEC - Spanish - Italian Congress on Thermodynamic of Metal Complexes – Sevilla, Spain, 5-9 giugno 2006.
8. M. Tegoni, Copper(II) 12-metallacrown-4 of α-, β- and γ-aminohydroxamic acids: a comparative study in aqueous solution, XVIII ISMEC - Italian-Spanish congress on the thermodynamics of metal complexes, Cagliari, 5-9 Giugno 2007. (Invited)
9. M. Tegoni, F. Dallavalle, M. Remelli, M. Lanfranchi; Structure and solution self-assembly equilibria of copper(II) metallacrowns of aminohydroxamic acids; XXXV Congresso Nazionale della Divisione di Chimica Inorganica della Società Chimica Italiana, Milano, 3 - 7 settembre 2007.
10. M. Tegoni, M. Remelli, F. Dallavalle, L. Marchiò; Lanthanide metallacrowns as anion receptors and potential MRI contrast agents; EUROBIC9 – 9th European Biological Inorganic Chemistry Conference; Wroclaw, Poland; 2-6 settembre 2008.
11. F. Dallavalle, M. Remelli, M. Tegoni; From eyes wide sut to eyes wide open – ten years in metallacrown chemistry; XX Italian-Spanish Congress on Thermodynamics of Metal Complexes; Tirrenia, Pisa; 7-11 giugno 2009.
12. Matteo Tegoni, Grazia Papini, Maura Pellei, Luciano Marchiò, Carlo Santini; Copper(II) complexes with macrocyclic N2S2 ligands: formation thermodynamics and interaction with human serum albumin; Biomet9 - 9th Workshop on Pharmaco-Bio-Metallics; Certosa di Pontignano, Siena; 6-8 novembre 2009.
13. M. Tegoni, M.L. Zastrow, V.L. Pecoraro; De novo designed Cu+/2+ metalloproteins as models for copper nitrite reductase; 10th PharmacoBioMetallics, Pozzuoli 28-29 ottobre 2010.
14. M. Tegoni, C. S. Lim, M. Remelli, F. Dallavalle, V. L. Pecoraro; 15-Metallacrown-5 complexes: thermodynamic and kinetic selectivity for core metal ions; XXII International Symposium on Metal Complexes, ISMEC 2011; Giardini Naxos (Italy), 13-16 giugno 2011.
15. M. Tegoni, De novo designed Type 2 copper metallopeptide as functional redox model of nitrite reductase, ArtZymes 2011 – Artificial metalloenzymes symposium, Marsiglia, Francia, 25-28 Settembre 2011. (Invited)
16. M. Tegoni, M. Bersellini, A. Bernardi, A. Quaranta, W. Leibl, V. L. Pecoraro; Copper metallopeptides as artificial enzymes; BioMet11 - 11th Workshop on PharmacoBioMetallics - San Benedetto del Tronto (AP), 28-30 ottobre 2011.
17. M. Tegoni, C. S. Lim, V. L. Pecoraro; 15-Metallacrown-5 complexes: how thermodynamics and kinetics drive the selectivity for core metal ions; 43rd Meeting of the Central Region of the American Chemical Society, Dearborn, MI, USA, 5-9 giugno 2012.
18. M. Tegoni, M. Bersellini, A. Bernardi, A. Quaranta, W. Leibl, V. L. Pecoraro; A route to artzymes: de novo designed copper metallopeptide as an artificial enzyme with nitrite reductase activity; EUROBIC11 - 11th European Biological Inorganic Chemistry Conference – Granada, Spain, 12-16 settembre 2012.
19. M. Tegoni, F. Yu, M. Bersellini, A. Quaranta, W. Leibl, V. L. Pecoraro; Copper artificial enzyme with nitrite reductase activity; DCSB 2012 – Convegno Nazionale della Divisione di Chimica dei Sistemi Biologici - Napoli, 24-25 settembre 2012.
20. M. Tegoni, M. Bersellini, A. Bernardi, A. Quaranta, W. Leibl, V. L. Pecoraro; Copper metallopeptides as artificial enzymes; BioMet12 - 12th Workshop on PharmacoBioMetallics - Padova, 26-28 ottobre 2012.
21. M. Tegoni, Designing a functional type 2 copper center that has nitrite reductase activity within α-helical coiled coils, Simposio finale della Chair Blaise Pascal del Prof. Vincent L. Pecoraro, Université Paris Sud, Parigi, Francia, 20 Novembre 2012. (Invited)
22. M. Tegoni, C. Atzeri, D. Capucci, M. Remelli, N. Marchetti, V.L. Pecoraro; Metallacrowns: controlling the assembly toward supramolecular constructs; ISMEC2014 – International Symposium on Metal Complexes – Pavia, Italy, 8-12 giugno 2014.
23. M. Tegoni, “Forever young”: the nice story of Metallacrowns from the perspective of a solution chemist, XIII International Symposium on Inorganic Biochemistry, Karpacz, Poland, 1-6 Settembre 2015. (Invited)
24. V. Marzaroli, C. Atzeri, C. Y. Chow, C. M. Zaleski, V. L. Pecoraro, M. Tegoni; Self-assembled copper and manganese metallacrowns as porous and magnetic materials; ICCC 2016 - 42nd International Conference on Coordination Chemistry, Brest, France, 3-8 luglio 2016.
25. M. Tegoni, NMR features of paramagnetic metallacrowns and metallacryptates containing Ln(III) ions, 1st International Symposium on Metallacrowns and Metallacryptates, Parma, 28-29 settembre 2017. (Invited)
26. M. Tegoni, D. Bellotti, C. Bacchella, A. Mazza, E. Quartieri, M. Remelli, S. Dell’Acqua, L. Casella, D. Valensin; Copper(II) binding to R1 and R3 fragments of Tau protein; CuBICS 2018 The Copper Bioinorganic Chemistry Symposium, Marsiglia, Francia, 21-24 maggio 2018.
27. V. Marzaroli, R. Polisicchio, L. Di Bari, C. M. Zaleski, V. L. Pecoraro, M. Tegoni; NMR and structural characterization of paramagnetic metallacrown architectures containing lanthanides; ISMEC 2018, International Symposium on Metal Complexes, Florence, 3-7 giugno 2018.
28. M. Tegoni, S. Gentili, E. Quartieri, D. Bellotti, M. Remelli, C. Bacchella, S. Dell’Acqua, L. Casella, D. Valensin; Copper(I) and copper(II) binding to R1 and R3 fragments of tau protein; ICBIC-19 19th International Conference on Biological Inorganic Chemistry, Interlaken, Switzerland, 11-16 agosto 2019. (Invited)
29. S.Gentili, G. Ferretti, G. Spagnoli, D. Cavazzini, M. Mattarozzi, A. Bolchi, S. Ottonello, M. Tegoni; new Artificial copper protein based on the SpyCatcher/SpyTag construct; ISMEC 2021 International Symposium on Thermodynamics of Metal Complexes; Białystok, Poland, 16-18 giugno 2021.
30. S.Gentili, G. Ferretti, A. Caruso, F. Bontempo, A. Bolchi, O. Iranzo, M. Tegoni; Developing designed copper – histidine sites in protein and peptides with redox catalytic behavior; 2nd European COST NECTAR Conference; Lisbon, Portugal, 25-27 agosto 2021.
31. M. Tegoni; Designing the SpyCatcher/SpyTag construct into a new artificial metalloprotein; Artificial proteins in the 21st century: Designed (metallo) proteins, Marseille, France, 6-8 Aprile 2022. (Invited)
32. C. Bottoni, E. Timpone, A. Ballerini, V. Borghesani, G. Spagnoli, A. Bolchi, M. Tegoni; Artificial catalytic copper proteins based on the spy technology; ISMEC 2023 International Symposium on Metal Complexes, Urbino, Italy, 11-14 giugno 2023.
33. M. Tegoni, C. Bottoni, V. Borghesani, F. Miglioli, S. Capodaglio, A. A. Bonini, A. Bolchi, G. Spagnoli, M. Malatesta; Designing spytag peptides: on the way to artificial copper enzymes; MBP 2024 2nd International Conference on Metal-Binding Peptides. Toulouse, France, 10-12 giugno 2024. (Invited)
34. M. Tegoni, V. Borghesani, F. Miglioli, C. Bottoni, S. Gentili, S. Capodaglio, A. Bonini, D. Bellotti, R. Guerrini, M. Remelli, G. Spagnoli, S. Ottonello, A. Bolchi; Redesign of spy protein into artificial cu(ii) proteins; EUROBIC 17 European Conference in Bioinorganic Chemistry; Munster, Germany, 25-29 agosto 2024.