Prof.

CURTI Claudio

Professore di II fascia
Settore scientifico disciplinare
CHIMICA ORGANICA (CHIM/06)
  • Curriculum Vitae
  • Office hour
  • Teaching
  • Appointments
  • Research

Curriculum Vitae of Prof. Claudio Curti

  1. PERSONAL INFORMATION

Family name, First name: Curti Claudio

Date of birth: 02/07/1975

Nationality: Italian

 

2.         BIBLIOMETRIC PROFILE

Research ID: D-1694-2013

ORCID-ID: 0000-0002-6117-1503

Scopus Author-ID: 7003325228

H-Index (10 Years): 20

H-Index (15 Years): 26

Total Publications: 56 (+3 book chapters, +2 patents)

Number of articles in the last 5 years: 18

Number of articles in the last 10 years: 36

Number of citations in the last 10 years: 1393

Number of citations in the last 15 years: 1935

 

3.         EDUCATION

2005    (110/110 e lode) postgraduate degree in Chemical Synthesis at the “Università Statale” of Milan (School of Chemical Synthesis), directed by Prof. Luisa Garanti.

2002    (106/110) Master degree in Pharmaceutical Chemistry and Technology at the University of Parma presenting an experimental thesis entitled "Asymmetric Synthesis of Pyranosidic Carbasugars", with the supervision of Prof. Giovanni Casiraghi and Prof. Franca Zanardi.

1994    Hi-School Diploma presso il Liceo Scientifico Statale “Aldo Moro” di Reggio Emilia.

1993    “Hononary Hi-School Diploma” - St. Joseph Hi-School di Victoria (Tx), USA.

 

4.         CURRENT POSITION

2017 – Associate Professor of Organic Chemistry SSD: CHIM/06

University of Parma, Department of Food and Drug, Parma, Italy

6.         RESEARCH INTERESTS

The research activity of Prof. Claudio Curti is centered upon important issues related to synthetic organic chemistry, focused on the study of the Principle of Vinylogy (Fuson, R. C. Chem. Rev. 1935, 16, 1) applied to the development of new asymmetric methodologies, mainly organocatalyzed vinylogous transformations, and their use in the synthesis of natural and non-natural biologically active compounds. In recent years, thanks also to the fruitful collaboration with Prof. Marco Lombardo (PI), his research interests focused on the development of organocatalyzed [4+2] cycloadditions exploiting the reactivity of in situ-formed, highly reactive ortho-quinodimethane (oQDM) species from a parent aromatic scaffold such as indole and uracil. These newly discovered methodologies represent important advancements opening the way to the synthesis of unprecedented chiral, enantiopure and polyfunctionalized bicyclic derivatives. In parallel to this methodological research, Prof. Curti activity is involved in a long lasting and fruitful collaboration with the nutrition group of the Department of Food and Drug at the University of Parma (Prof. Daniele del Rio) on the development of stereoselective syntheses of chiral secondary metabolites of polyphenols and their biological conjugates.

 

5.         FELLOWSHIPS

2002    1-year fellowship “Feliciani Ferretti” CHIM-06 Organic Chemistry, “Asymmetric Synthesis of Bioactive Glicopeptidomimetics” with Prof. G. Casiraghi.

2003    1-year fellowship “Feliciani Ferretti” CHIM-06 Organic Chemistry, “Development of Stereoselective Synthetic Methodologies to Access Biological Relevant Molecules” with Prof. G. Casiraghi.

 

7.         MAJOR NATIONAL AND INTERNATIONAL COLLABORATIONS

-           Department of Chemistry "Giacomo Ciamician", University of Bologna (Prof. Marco Lombardo)

-           Department of Microbiology, Immunology and Transplantation, KU Leuven (Prof. Kurt Vermeire)

-           Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma (Prof. Pelosi, Prof. Ottonello)

-           Department of Food and Drug, University of Parma (Prof. Del Rio, Prof. Mor, Prof. Lodola)

-           Istituto di Chimica Biomolecolare del CNR, Sezione di Sassari, Sassari. (Dr. Rassu)

-           Department of Chemistry, Università degli Studi di Milano (Prof. C. Gennari)

-           Divisione di Strutturistica Molecolare, National Institute for Medical Research, London, UK.

-           Unità di Medicina Nucleare, Dipartimento di Imaging, Azienda Ospedaliero-Universitaria di Parma.

-           Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale e Clinica, Università degli Studi di Parma.

-           Istituto di Chimica Organica, Università degli Studi di Urbino “Carlo Bo” di Urbino (Prof. Gianfranco  Favi)

-           Unilever R&D Vlaardingen B.V., Nederland (Dr. Arno Greyling, Research Scientist Cardiovascular Health)

-           University of Cambridge Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK

-           Wellcome Trust Sanger InstituteWellcome Trust Genome Campus, Hinxton, Cambridge, UK

-           NNEdPro Global Centre for Nutrition and, St John’s Innovation Centre, Cambridge, UK

-           Department of Food Biotechnology and Microbiology, Institute of Food Science Research (CIAL), CSIC-UAM, Madrid, Spain

 

8.         FUNDING

PRIN 2006: (dal 09/02/2007 al 09/02/2009) “Sintesi e Sviluppo di Nuovi Ligandi Integrinici a Base RGD e Loro Coniugati” PI: Prof. Gennari, Unit Leader: Prof. Casiraghi. (Area 03) – ROLE: Unit Component -

PRIN 2008: (dal 22/03/2010 al 22/09/2012) “Recettori integrinici a riconoscimento RGD. Sintesi ed applicazioni biomediche di ligandi integrinici RGD a nucleo pirrolidinico e ciclopentanico e loro coniugati.” PI: Prof. Gennari, Unit Leader: Prof. Zanardi. (Area 03)  - ROLE: Unit Component –

PRIN 2010-2011: (dal 01/02/2013 al 01/02/2016) “Sintesi e applicazioni biomediche di peptidomimetici in campo oncologico” PI: Prof. Gennari, Unit Leader: Prof. Zanardi. (Area 03) - ROLE: Unit Component –

PRIN 2015: (dal 05/02/2017 al 05/02/2020) “Tumor-targeting peptidomimetics: synthesis and bio-medical applications” PI: Prof. C. Gennari, Unit Leader: Prof. Zanardi. (ERC PE5)  - ROLE: Unit Component –

PRIN 2020: (from 2021) “Synthesis and biomedical applications of tumor targeting peptidomimetics and conjugates” PI: Prof. F. Formaggio, Unit Leader: Prof. F. Zanardi. (ERC PE5).  - ROLE: Unit Component –

9. EDITORIAL ACTIVITIES

2005-today     Reviewer for Wiley (Chemistry Eur. J, Eur. J. Org. Chem., Adv. Synth. Catal.), ACS (Org. Lett., J. Org. Chem.) and RSC (RSC Advances), Nature publishing (Scientific Reports), MDPI (Molecules, Catalysts).

2021-today     Review Editor of Frontiers in Organocatalysis (Frontiers in Catalysis)

 

Editing of the Italian edition of the following volumes:

2015    Brown, W. H.; Iverson, B. L.; Anslyn, E. V.; Foote, C.S. Chimica Organica, 5th Ed. Edises. ISBN: 9788879598309

2016    Silverstein, R. M.; Webster, F. X.; Kiemle, D. J.; Bryce, D. L. Identificazione Spettrometrica di Composti Organici, 3rd Ed., CEA. ISBN: 978-8808-18350-7

2018    Brown, W. H.; Iverson, B. L.; Anslyn, E. V.; Foote, C.S. Chimica Organica, 6th Ed. Edises. ISBN: 9788833190556

 

10. TEACHING ACTIVITIES

Since 2006, Claudio Curti has taught and continues to teach in his department both as a teacher of official courses (Teaching assignments and 6.2 Participation in Examination Committees), and as a tutor for the training of many students for the development of their thesis, being speaker or co-rapporteur of several dissertations. In this context, the candidate has carried out and continues to carry out tutoring activities for doctoral and post-doctoral students for the conduct of their research. Finally, prof. Curti has taught courses in English abroad at the ULLA Summer School for PhD students.

 

Teaching assignments

2006-2007:     Researcher - Integrative Didactics for the teaching of "Propaedeutic Organic Chemistry" – Degree in Pharmacy, Faculty of Pharmacy, University of Parma. (5 CFU)

2007-2009:     Assistant Professor - “Organic Chemistry” – Degree in Scientific Information on Drugs - Faculty of Pharmacy, University of Parma. (8 CFU)

2009-2010:     Assistant Professor - “Organic Chemistry” – Degree in Applied Pharmaceutical Sciences - Faculty of Pharmacy, University of Parma. (8 CFU)

2011-today:    Assistant and Associate Professor - “Organic Chemistry II” for the Master Degree in Pharmaceutical Chemistry and Technology - University of Parma. (8 CFU).

2017-2018:     Assistant Professor - “Advanced Organic Syntheses” – Master Degree in Pharmaceutical Chemistry and Technology - Faculty of Pharmacy, University of Parma. (4 CFU)

2019-today: Associate Professor - “Innovative Syntheses of Chiral Drugs” for the Master Degree in Pharmaceutical Chemistry and Technology - University of Parma. (4 CFU).

2019-today: Associate Professor - “Chemistry” for the Degree in Gastronomic Science - University of Parma. (9 CFU).

 

International Teaching Activities

2011    Zanardi, F.; Battistini, L.; Curti, C.Method- and Target-Oriented Organic Synthesis:Invaluable Opportunities in Contemporary Drug Discovery”. 10th ULLA Summer School, July 2-8, 2011, Parma, Italy (One-day Course).

2017    Curti, C.Asymmetric organocatalysis at the service of medicinal chemistry”. 13th ULLA Summer School, July 8-15, 2017, KU Leuven, Belgium (One-day Course)

2017    Curti, C.Stereochemistry in Drug Synthesis and Development”. 14th ULLA Summer School, June 29 - July 5, 2019, Helsinki, Finland (Two-day Course)

 

Co-Tutoring of PhD Thesis

2017    PhD in Food Science, XXIX Cicle). Co-Tutoring with Prof. Daniele del Rio. PhD candidate: Nicoletta Brindani: “Development of New Synthetic and Analytical Methods for the Investigation of Specific Polyphenolic Human Metabolites”. University of Parma

 

11. Institutional Responsibilities

2008-today:    Doctorate School member

2003-today:    Faculty member

2020-today:    Quality Assurance Delegate (RAQ) – Single Cycle Degree/Combined Bachelor and Master in Pharmaceutical Chemistry and Technology – Department of Food and Drug - University of Parma.

Friday 9.30:11.30

Everyday by appointment by mail

Anno accademico di erogazione: 2022/2023

Anno accademico di erogazione: 2021/2022

Anno accademico di erogazione: 2020/2021

Anno accademico di erogazione: 2019/2020

Anno accademico di erogazione: 2018/2019

Anno accademico di erogazione: 2017/2018

Anno accademico di erogazione: 2016/2017

Anno accademico di erogazione: 2015/2016

Anno accademico di erogazione: 2014/2015

Professor/Teacher

Teacher tutor

Lines of research

The research activity of Prof. Claudio Curti began concretely in 2001 and has continued until today focusing on important issues mainly related to organic chemical synthesis, with particular regard to the study of the Principle of Vinylogy (Fuson, R. C. Chem. Rev. 1935, 16, 1), applied to the development of new asymmetric methodologies and their use in the synthesis of biologically active natural and non-natural compounds . More recently, the scientific activity of Prof. Claudio Curti in the methodological field of organic transformations has focused on the study of "direct and indirect" stereoselective transformations promoted by organic (organocatalysis) and/or metallic chiral catalytic systems. The objective of this research is the exploration of the reactivity of conjugated organic systems based on iliden-heterocyclic, whose in situ enolization by appropriate chiral catalysts generates gamma-selective multi-toothed vinyl nucleophils to be exploited in asymmetric reactions for the stereoselective synthesis of chiral and enantiopure bioactive molecules. Furthermore, an important branch of multidisciplinary research that has involved Claudio Curti in recent years, concerns the metabolomics of active components present in foods such as polyphenols, tannins and derivatives. Polyphenols and their related compounds are a group of secondary metabolites of plant origin that, according to epidemiological studies, play an important role in the protective effects of a diet based on fruits and vegetables. Recently, great attention has been paid to the role played by flavan-3-ols in the prevention of chronic diseases; in fact, there is substantial in vitro evidence of their influence in different processes in mammalian cells. The scientific evidence accumulated in the last decade indicates that the beneficial effects of flavan-3-ols could be attributed not so much to the original compounds, but to the corresponding conjugated metabolites and mainly to those derived from the microbial catabolism of epicatechins and proanthocianidins (i.e. γ-valerolactones). γ-valerolactones and their conjugates sulfated and glucuronidated are not commercially available and, being mixed human/microbial metabolites, it is not possible to isolate them from biological matrices in appreciable quantities. To solve this issue, asymmetric synthesis represents an attractive approach for accessing enantiopure compounds in useful quantities. In collaboration with the group of Prof. Daniele Del Rio of the Department of Veterinary Science, an efficient, versatile and divergent synthetic plan has been developed with the aim of obtaining, in both enantiomeric forms, a series of non-conjugated γ-valerolactonic metabolites (aglicones), and some of their sulphated liver conjugates and/or glucuronidates. Through national and international collaborations, these synthetic derivatives have been exploited as "analytical standards" and as "analytical standards". either tested in vitro as modulators/protectors of brown adipocytes, implicated in cardiovascular risk; or as inhibitors of the adhesiveness of uropathogenic Escherichia coli.

Publications

Orcid

Orcid: 0000-0002-6117-1503 ResearcherID: D-1694-2013 Scopus Author ID: 7003325228

Contacts

Phone number
905080
Fax number

905006

Office location

Building "Farmacia"

Corpo B-SUD