Prof.

CURTI Claudio

Professore di II fascia
Settore scientifico disciplinare:
CHIMICA ORGANICA (CHIM/06)
  • Curriculum Vitae
  • Office hour
  • Teaching
  • Appointments
  • Research

1. Biography and Education

Dr. Claudio Curti was born in Correggio (Reggio Emilia, Italy) in 1975. He received an “honorary Hi-School” Diploma at the St. Joseph Hi-School of Victoria-Tx (USA) in 1993, at the end of a one year “exchange student” program fellowship. In 1994 he graduated from Liceo Scientifico Statale “Aldo Moro” in Reggio Emilia.

In 2002 he graduated in Medicinal Chemistry at the University of Parma presenting an experimental thesis entitled "Asymmetric Synthesis of Pyranosidic Carbasugars", with the supervision of Prof. Giovanni Casiraghi and Prof. Franca Zanardi.

In April 2002 he received a one-year post-graduate fellowship in Organic Chemistry for a research programme on "Asymmetric Synthesis of Bioactive Glycopeptidomimetics"  During this period he improved his skills in the field of asymmetric multistep organic synthesis, working on the development of new synthetic strategies toward biologically and pharmaceutically relevant multifunctional molecules, such as carbasugars, amino sugars, structurally modified amino acids, and acyclic nucleoside analogues.

In 2002 (Second Session), he received the professional qualification for the pharmacist profession.

In October 2003 he received a second one-year post-graduate fellowship in Organic Chemistry  for a research on the "Development of New Stereoselective Synthetic Methodologies toward Biologically and Pharmaceutically Relevant Molecular Targets”.

In March 2005 he graduated  (110/110 e lode) from the postgraduate School of Chemical Synthesis at the “Università Statale” of Milan, directed by Prof. Luisa Garanti, attending courses about: synthetic methodologies, analitical methodologies, patent applications and bibliographical data, biological systems in Organic Chemistry, Structure-Activity Relationship and Drug Design.

In January 2005 he was appointed  "Ricercatore Universitario" (CHIM/06-Organic Chemistry, D.R. n.365 del 19.01.2005), at the University of Parma at the Faculty of Pharmacy (Pharmaceutical Department).

In May 2008 he was appointed  "Ricercatore Universitario Confermato" (CHIM/06-Organic Chemistry, D.R. n° 662 del 28/05/2008)

In November 2014 he obtained the national scientific qualification (ASN 2013, DD n.161/2013) for the role of Associate Professor of Organic Chemistry.

In December 2017 he was appointed Associate Professor of Organic Chemistry (D.R. 2975 del 20.12.2017) of the University of Parma, working at the Department of Food and Drug .

 

 

Friday 9.30:11.30

Everyday by appointment by mail

Anno accademico di erogazione: 2020/2021

Anno accademico di erogazione: 2019/2020

Anno accademico di erogazione: 2018/2019

Anno accademico di erogazione: 2017/2018

Anno accademico di erogazione: 2016/2017

Anno accademico di erogazione: 2015/2016

Anno accademico di erogazione: 2014/2015

Professor/Teacher

Teacher tutor

Lines of research

The research activity of Prof. Claudio Curti began concretely in 2001 and has continued until today focusing on important issues mainly related to organic chemical synthesis, with particular regard to the study of the Principle of Vinylogy (Fuson, R. C. Chem. Rev. 1935, 16, 1), applied to the development of new asymmetric methodologies and their use in the synthesis of biologically active natural and non-natural compounds . More recently, the scientific activity of Prof. Claudio Curti in the methodological field of organic transformations has focused on the study of "direct and indirect" stereoselective transformations promoted by organic (organocatalysis) and/or metallic chiral catalytic systems. The objective of this research is the exploration of the reactivity of conjugated organic systems based on iliden-heterocyclic, whose in situ enolization by appropriate chiral catalysts generates gamma-selective multi-toothed vinyl nucleophils to be exploited in asymmetric reactions for the stereoselective synthesis of chiral and enantiopure bioactive molecules. Furthermore, an important branch of multidisciplinary research that has involved Claudio Curti in recent years, concerns the metabolomics of active components present in foods such as polyphenols, tannins and derivatives. Polyphenols and their related compounds are a group of secondary metabolites of plant origin that, according to epidemiological studies, play an important role in the protective effects of a diet based on fruits and vegetables. Recently, great attention has been paid to the role played by flavan-3-ols in the prevention of chronic diseases; in fact, there is substantial in vitro evidence of their influence in different processes in mammalian cells. The scientific evidence accumulated in the last decade indicates that the beneficial effects of flavan-3-ols could be attributed not so much to the original compounds, but to the corresponding conjugated metabolites and mainly to those derived from the microbial catabolism of epicatechins and proanthocianidins (i.e. γ-valerolactones). γ-valerolactones and their conjugates sulfated and glucuronidated are not commercially available and, being mixed human/microbial metabolites, it is not possible to isolate them from biological matrices in appreciable quantities. To solve this issue, asymmetric synthesis represents an attractive approach for accessing enantiopure compounds in useful quantities. In collaboration with the group of Prof. Daniele Del Rio of the Department of Veterinary Science, an efficient, versatile and divergent synthetic plan has been developed with the aim of obtaining, in both enantiomeric forms, a series of non-conjugated γ-valerolactonic metabolites (aglicones), and some of their sulphated liver conjugates and/or glucuronidates. Through national and international collaborations, these synthetic derivatives have been exploited as "analytical standards" and as "analytical standards". either tested in vitro as modulators/protectors of brown adipocytes, implicated in cardiovascular risk; or as inhibitors of the adhesiveness of uropathogenic Escherichia coli.

Publications

Orcid

Orcid: 0000-0002-6117-1503 ResearcherID: D-1694-2013 Scopus Author ID: 7003325228

Contacts

Phone number
905080
Fax number

905006

Office location

Building "Farmacia"

Corpo B-SUD