Personale docente

PRESENT POSITIONS

Full Professor of Hematology at the University of Parma, Italy

Titles and Positions

• (07/09/1993) Graduated in Medicine and Surgery at the University of Florence (Italy) with the score of 110/110 and “first class honors degree”.
• (11/29/1999) Residency in Internal Medicine at the University of Parma (Italy) with the score of 50/50 and “first class honors degree”.
• (March 1999-September 2000) Fellowship in Hematology at the INSERM U463, Nantes (France) on the pathophysiology of bone lesions in multiple myeloma and the role of RANKL in myeloma-induced osteoclast formation. (Prof. Regis Bataille)
• (January 2000-2003) PhD degree at the University of Parma with a thesis entitled: “Role of RANKL in the pathophysiology of bone lesions in multiple myeloma”
• (February 2001-November 2010): Assistant Professor in Hematology belonging at the “Cattedra di Ematologia” of the University of Parma.
• (November 2010-2021). Associate Professor of Hematology at the University of Parma.
• (November 2010-until now). Head of the Research Laboratory of Hematology at the University of Parma on multipe myeloma research

• 2017 Qualification to Full professor in Hematology, Internal medicine, Clinical Pathology, and medical Technology.
• March 2021 until now: Full Professor in Hematology

Participation in committees and istitutional roles

• Member of the board of the Ph.D. in “Medical Science” of the University of Parma from 2011 until now.
• Member of the Local Research Board of the “Azienda Ospedaliero-Universitaria di Parma” from April 2011 to 2014.
• Member of “Jury de thèse” at the University of Nantes (France), October 2009
• Member of the Medical Research Committee of the University of Parma from 2011 to 2025
• Member of Scientific Committee of Italian Association for Cancer Research (AIRC) from 2018-2023
• Memeber of the board of the European Myeloma Network Research Italy from 2017 until now
• Member of the Scientific  Board of the "Società Italiana di Ematologia Sperimentale" (SIES) from 2014 to 2018.
• Course Director of the Medical, Veterinary and Pharmaceutical Biotechnology Maaster of Science   at the University of Parma (LM-9)
• Director of the Post-graduate Residency in Hematology at the University of Parma from 2019-2022 and from 2026
• Head of the MASTER of II° level in “Stem cell and Regenerative Medicine of the University of Parma from 2011 to 2022

Awards and Grants

International

• Award Grant of the “Ligue Nationale Contre le Cancer", Nantes, (France), 1999-2000.
• “Young Investigator Award” of the American Society for Bone and Mineral Research (ASBMR) in the 2001 for the work entitled: “Human myeloma cells upregulate RANKL and downregulate OPG in Bone Environment: Evidence of OPG/RANKL Imbalance in Multiple Mieloma patients”
• “Travel Grant” at the annual meeting of International Society of Experimental Hematology (ISEH) in 2003 and 2004.
• “Travel Grant” al “Vth International Conference on cancer-induced bone disease”, Davos (Svizzera), 2005.
• Junior Award Grant of the ”International Myeloma Foundation” in 2006 for the work entitled: “Role of Wnt and Runx2 pathways in the inhibitions of osteoblasts in multiple myeloma patients”
• Senior Award Grant of the”International Myeloma Foundation” in the 2009 for the work entitled: “Study of alterations of bone microenvironment cells in multiple myeloma patients in relationship with osteolytic bone lesions: identification of potential new therapeutic targets”.
• Senior Award Grant of the “International Myeloma Foundation  Brian D. Novis” in the 2018 for the research: “Reprogramming MM cell metabolism to affect bone disease in Multiple Myeloma.
• "International Myeloma Society (IMS) and Paula and Rodger Riney Foundation Translational Research Grant in 2021: Glutamine metabolism as new marker and diagnostic tool for bone disease in multiple myeloma patients.
• Global Medical Grants Pfizer 2022-2023: “Characterization and targeting of myeloma cancer stem cells to overcome resistance to anti-BCMA treatment”

National

• Group Leader of Grants of the Italian Minister of University and Research (MIUR)  PRIN for the research projects entitled:
  • “Espressione e ruolo delle isoforme del recettore chemochinico CXCR3 nella fisiopatologia del mieloma multiplo e delle neoplasie B” in the 2004;
  • “Alterazioni del microambiente osseo nel mieloma multiplo: meccanismi biologici e ruolo patogenetico” in the 2006, 
  • “NUOVI FARMACI NEL TRATTAMENTO DEL MIELOMA MULTIPLO: VALUTAZIONE DEL LORO EFFETTO A LIVELLO DEL MICROAMBIENTE OSSEO E IDENTIFICAZIONE DI MARCATORI PROGNOSTICI MOLECOLARI” in the 2009.
• Principal Investigator of the  Grant of the Italian Minister of University and Research (MIUR) PRIN for the research projects entitled “RandoMMness: the heterogenous spatial distribution of Multiple Myeloma unveiled by liquid biopsy “ in the 2022.
• Principal Investigator of the Grant of the “Associazione Italiana Ricerca sul Cancro” (AIRC), Grant application IG2009 for a project entitled “Bone cell alterations in multiple myeloma patients and effects of new drugs”.
• Group Leader of the Grant AIRC 5/1000 Special Program Molecular Clinical Oncology, in 2010, with a project entitled “Harnessing tumour cell/microenvironment cross talk to treat mature B-cell tumours”. (Cord. Prof. Caligaris Cappio).
• Principal Investigator of the Grant of the “Associazione Italiana Ricerca sul Cancro” (AIRC), Grant application IG2014 for a project entitled “HYPOXIC NICHE AS A POTENTIAL THERAPEUTIC TARGET IN MYELOMA BONE MICROENVIRONMENT”.
• Principal Investigator of the IG2017-2022 of the “Associazione Italiana Ricerca sul Cancro” (AIRC) for a project entitled "Glutamine metabolism for targeting and imaging in myeloma bone microenvironment".
• Principal Investigator of the “Ministero della salute Ricerca Finalizzata 2016”, for the Italian researcher abroad project entitled "IDENTIFICATION AND VALIDATION OF CRITICAL 1q21 ACHILLE’S HEEL VULNERABILITIES IN MULTIPLE MYELOMA PATIENTS.”
• Principal Investigator of the PNRR program  entitled: Role of metabolic alterations of the bone microenvironment in the immune-suppression and tumoral progression in multiple myeloma PNRR-MCNT1-2023-12377835 in the 2023. 

Main Oral presentations at International Congress with referee

•      “American Society of hematology” (ASH): oral communication at the annual meeting in the 2001, 2004, 2006 (2 communications), 2009 (4 communications), 2010 (2 communications), 2014 and 2016.

•      “European Society of hematology” (EHA): oral communication at the annual meeting in the 2002, 2003 and 2007.

•      International Society for Experimental hematology” (ISEH): oral communication at the annual meeting in the 2003, 2004, 2005, 2006, 2007 and 2008.

Invited lectures at foreign Universities, Institutions and International Congress

• “Multiple Myeloma bone disease: from the pathophysiology to the treatment” (Invited by O. Sezer), Berlin, May 2007
• “Pathophysiology of Multiple Myeloma bone disease”, Harvard Medical School, Masachussetts General Hospital, Boston, MA (Invited by Dr. Noopur Raje) July 2008
• “Pathophysiology of Multiple Myeloma bone disease and the effects of the new drugs on the bone microenvironment” Centre Pluridisciplinaire d'Oncologie, CFH, Lausanne, Suisse (Invited by Dr. Nicholas Ketterer, April 2009.
• "Eleventh International ABMT Symposium", Arlington, (USA), 2002
• “Eurocancer 2008”, Parigi (Francia), 2008
• “Eticho Multiple Myeloma 2010 course”, Madrid, May, 2010
• “13th International Myeloma Workshop”, Paris, May 2011

Main Chair, co-chair or key faculty member of Congress

•          2011: MEMBER OF THE SCIENTIFIC COMMITTEE OF THE 13TH INTERNATIONAL MYELOMA WORKSHOP, PARIS (FRANCE)

•          2012: SCIENTIFIC ORGANIZER OF “MIELOMA MULTIPLO: FROM THE BENCH TO THE BEDSIDE”/PARMA (ITALY)

•          2014: SCIENTIFIC ORGANIZER OF “INIBITORI DEL PROTEASOMA E FARMACI IMMUNOMODULANTI NEL MIELOMA MULTIPLO: COSA C’È DI NUOVO?”/PARMA (ITALY)

•          2016: SCIENTIFIC ORGANIZER OF NATIONAL CONGRESS OF THE ITALIAN SOCIETY FOR EXPERIMENTAL HEMATOLOGY (SIES), RIMINI (ITALY)

 •         2018: SCIENTIFIC ORGANIZER OF NATIONAL CONGRESS OF THE ITALIAN SOCIETY FOR EXPERIMENTAL HEMATOLOGY (SIES), RIMINI (ITALY)

•          2016. SCIENTIFIC ORGANIZER OF “LA GESTIONE DEL PAZIENTE ANZIANO CON IL MIELOMA MULTIPLO: UN APPROCCIO MULTIDISCIPLINARE”/PARMA, (ITALY)

•          2018: SCIENTIFIC ORGANIZER OF THE “1° MEETING TRI-REGIONALE EMILIA-TOSCANA-LIGURIA SU GAMMAPATIE MONOCLONALI E MIELOMA MULTIPLO”, BERCETO (PR), (ITALY)

•          2021: SCIENTIFIC ORGANIZER OF THE “MYELOMA RESEARCH WORKSHOP: FROM THE BEDSIDE TO THE BENCH”/PARMA (ITALY).

•          2024: SCIENTIFIC ORGANIZER OF THE KICK-OFF MEETING " CD38 E NUOVI POSSIBILI BERSAGLI NEL MIELOMA MULTIPLO" , SAN BENEDETTO PO (MANTOVA), (ITALY)

Memberships of Scientific Societies: He is member of the International Society of Experimental Hematology (ISEH) and of the American Society of Hematology (ASH), Italian Society of Experimental Hematology (SIES) and Italian Society of Hematology (SIE), International Myeloma Society.

Editorial Board

-ASSOCIATE EDITOR FOR FRONTIERS IMMUNOLOGY from 2018-until now, 

Peer reviewer activity: Peer reviewer activity for the following main Journals: Blood, Leukemia, Haematologica, Blood Advances, J Clin Invest, Bone, Front Oncol, Front Immunol, Nat Commun, Nat Med, Sci Rep.

-AMERICAN SOCIETY OF HEMATOLOGY(ASH), EDUCATION PROGRAM BOOK (2008)

Clinical Research Activity

He exerted clinical activity from March 2001 until 3/10/2018 at the Hematological Unit of the University Hospital of Parma (Italy). He was:

• “Case Manager from” 1/02/2001 to 01/07/2006
• “Case Manager Esperto” dal 01/07/2006 until 03/10/2018
• “Responsabile di Programma Dipartimentale sul Mieloma Multiplo e gammapatie Monoclonali” dell’”Azienda Ospedaliero-Universitaria di Parma” from October 2021 until now.

BIBLIOMETRIC INDEXES

• Number of pubblications: 184 (181 as author and 3 as collaborator)

• Impact factor (IF): 1337 (IF average: 7.3)
• IF first/last and/or “corresponding” (n° 101): 506 (IF average: 5)
  • IF first author 197 (n°36)
  • IF last author and/or corresponding author 381 (n° 65)
• WOS: H-index 51; Sum of Times Cited; 9,094 Citing Articles 7,093
• SCOPUS: H-index 55; Total citations 9,195 by 7,044 documents 191 Documents by Author
• ORCID ID: https://orcid.org/0000-0003-3457-3774