Born in Bologna, August 12, 1969.
1995 Graduate
Degree in Medicine and Surgery with vote 110/110 cum laude at the University of Bologna with a discussion of thesis entitled "epileptic negative myoclonus: clinical and neurophysiological features."
1995 Authorization to practice the profession of Doctor - Surgeon. Joined the Professional Order of Physicians - Surgeons and Dentists of the Province of Bologna.
POSTGRADUATE EDUCATION - UNIVERSITY OF BOLOGNA
1995-1999 Residency in Neurology
Achieved by voting 70/70 cum laude with a discussion of thesis entitled "Polygraphic study of myoclonus, spasms and tonic seizures in epileptic patients."
1999-2002 PhD in Applied Physiology and Pathophysiology.
Degree at the University of Bologna with a discussion of thesis: The recognition of emotions in patients with mesial temporal epilepsy.
2003-2006 Research Fellowship at the Department of Neurological Sciences, University of Bologna. Program of research and training: application of neurophysiological and functional imaging techniques in the study of brain activity in patients candidates for surgical therapy of epilepsy.
ACTUAL POSITION - UNIVERSITY OF PARMA (since May 16, 2026)
Associate Professor in Neurology. Department of Medicine and Surgery
Director of Neurology Unit, AOU Parma
PREVIOUS POSITIONS
2017- 2026 Director of neurophysiology Unit, AOU Modena
2018 –2024 Director of Neurology Unit, AOU Modena
2018 -2024 Director post-graduate school in Neurology, University of Modena e Reggio Emilia
2007–2017 Permanent University Researcher in Neurology, University of Modena and Reggio Emilia
2003-2006 Post-doc researcher position. Dipartimento delle Scienze Neurologiche, University of Bologna. Research program: “application of neurophysiology and functional imaging techniques in patients candidate to surgical therapy of epilepsy”
2002–2004 Post-doc researcher position. Epilepsy surgery centre “C.Munari” Ospedale Niguarda Ca Granda, Milan
2000-2002 Consultant in Neurology at AUSL di Imola
AWARDS, HONORS, QUALIFICATIONS, and TITLES
2026 Elected Co-Chair Epilepsy Scientific Panel of the European Academy of Neurology (EAN) for the years 2026-2028
2018 Achievement of eligibility to hold the position of Full Professor in Neurology, 06/D6 (ASN 2016)
2017 Achievement of the degree in Management for the Management of Complex Health Facilities - Marco Biagi University Foundation. University of Modena and Reggio Emilia. Achievement of the title from 21-11-2017
2017 Achievement of eligibility to hold the position of Associate Professor in Neurology, 06/D6 (ASN 2016)
2012 Achievement of eligibility to hold the position of Associate Professor in Child Neuropsychiatry, 06/G1 (ASN 2012)
2012 Achievement of eligibility to hold the position of Assistant Professor in Physiology, 05/D1 (ASN 2012)
2003 Award for culture and scientific merits of the Lega Italiana contro l’Epilessia
2002 Award for culture and scientific merits of the Lega Italiana Contro l’Epilessia
1999 Young Investigator Fellowship International Federation of Clinical Neurophysiology (I.F.C.N.)
MEMBERSHIPS IN ACADEMIES AND SCIENTIFIC SOCIETIES
2019 - European Academy of Neurology. From 2023: Member of the Management Group of the Epilepsy Scientific Panel. From 2026: Co-Chair Epilepsy Scientific Panel
2016 - American Epilepsy Society.
2014 - Italian Society of Clinical Neurophysiology. (SINC). Since 2021 member of the executive board ‘Consiglio Direttivo’. Since 2024 chair of the study group ‘Intra-operative neurophysiological monitoring and critical care EEG’
2001 - Italian Society of Neurology (Società Italiana di Neurologia - SIN). Since 2019 member of the ‘epilepsy study group’.
1996 - Lega Italiana Contro l’Epilessia (LICE): Italian League Against Epilepsy (National Chapter of the International League against Epilepsy). From 2015 to 2020 member of the executive board ‘Consiglio Direttivo’. Since 2020 Chair of the Commission for Neurophysiological Techniques. Since 2023 member of the Scientific Committee.
ROLE IN PUBLIC INSTITUTIONS and SCIENTIFIC SOCIETIES
2026 - Director of Neurology Unit, Azienda Ospedaliera - Universitaria. Parma, Italy.
2017 –2026 Prof. Meletti holds the position of Director of the Clinical Neurophysiology Unit of the University Hospital of Modena (since 07/23/2017). The activities of the Neurophysiology Unit are spread over 3 hospital wards: Civil Hospital of Baggiovara, Polyclinic of Modena, Hospital of Pavullo nel Frignano. The Neurophysiology Unit has 4 "Epilepsy Monitoring Unit" beds dedicated to inpatients monitoring of complex epilepsies. Activities include neurophysiological diagnostics for outpatients and inpatients. Among the various activities, intraoperative neurophysiological monitoring activities and EEG monitoring activities in the intensive care unit have particular relevance.
In addition, the activities of the Epilepsy Center and the Epilepsy Monitoring Unit are carried out by staff with specific expertise in epileptology and neurophysiology.
2019- Coordinates the Comprehensive Epilepsy Program and Diagnostic Therapeutic Care Pathway for Epilepsy Surgery for the University Hospital of Modena. With DGR 1172/2018, the Emilia-Romagna Region formalized the establishment of an Hub Center for Epilepsy Surgery, which provides for the establishment of a care pathway for the selection of patients with drug-resistant focal epilepsy to undergo resective surgery. The two referral sites of the HUB Center are the IRCCS-ISNB of the Ausl of Bologna and the Ospedale Civile Baggiovara of the AOU of Modena, to which the spoke epilepsy centers send, according to a territorial criterion of afference, patients potentially eligible for surgical therapy.
2017- Coordinates the working group: Diagnostic Therapeutic Care Pathway for the diagnosis and treatment of Adult Status Epilepticus for the University Hospitals of Modena.
2018 – 2024 Prof. Meletti held the position of Pro-tempore Director of the Neurology Unit of the University Hospital of Modena located at the Baggiovara Civil Hospital (since 01/11/2018). The facility consists of 28 ordinary inpatient beds and 6 "Stroke Unit" sub-intensive care beds. It coordinates the activities of 21 Neurologists and Neurophysiologists.
2022-2024 Coordination of Time-Dependent Pathology Networks for AOU Modena-AUSL Modena. The program aims to implement the respective PDTAs (stroke, status epilepticus, trauma, myocardial infarction) at the Modena province level and the implementation of a monitoring plans of outcome and performance indicators.
2023 - Participates in the Neuroscience Network Group of the Emilia - Romagna Region. Resolution No. 154 of 08/02/2021.
2023 - Management Group of the Epilepsy Scientific Panel of the European Academy of Neurology.
2021- Co-Chair of the Epilepsy and Neurophysiological Techniques Commission of the Italian League Against Epilepsy (LICE). The commission aims to promote collaborative research and studies in neurophysiology among epilepsy centers operating nationwide, and the production of position papers on the use of different neurophysiological diagnostic methods in epilepsy.
2018-2020 Chair of the High-Density EEG Study Group of the Italian Society of Clinical Neurophysiology (SINC). Collaborative networks for the development of scientific studies among researchers using 'high-density EEG' and MEG.
2015-2020 Founder and Chair of the Neuroimaging Commission of the Italian League Against Epilepsy (LICE). The committee aims to promote collaborative research and studies in neuroimaging among epilepsy centers operating in the country.
2012-2016 Chair of the Video Library Commission of the Italian League Against Epilepsy (LICE). The commission is responsible for promoting research and knowledge of semiological aspects of epileptic seizures for localization and diagnostic purposes.
EDITORIAL BOARD ACTIVITIES
2025- Associate Editor for Clinical Neurophysiology Practice.
2022- Associate Editor for Frontiers in Neurology – Epilepsy section.
2016- Editorial board member for Epileptic Disorders.
2015-2020 Editorial board member for “Clinical Cases and Reviews in Epilepsy”.
2016-2020 Academic Editor for PLoS One.
Reviewer for the following journals:
Archives of General Psychiatry; BMC Neurology; Brain; Brain Topography; Epilepsia; Epilepsy Research; Epilepsy & Behavior; Epileptic Disorders; Critical Care Medicine; CNS Drugs; Cognitive Affective & Behavioral Neuroscience; Cortex; European Journal of Neurology; Journal of Neurology, Neurosurgery, and Psychiatry; Frontiers in Neurology; Journal of Neurological Sciences; Neurology; Neuroimage; Neurology Clinical Practice; Human Brain Mapping; Neuropsychologia; PLoS One; Scientific Reports; Seizure; Sleep.
RESEARCH ACTIVITIES
Prof. Meletti has devoted his research activities mainly to the field of central nervous system diseases, from functional semeiotics to neurophysiological and neuroimaging diagnostics. Specific fields of expertise are neurophysiology and epileptology. In particular, he has devoted himself to the study of pathophysiological mechanisms of different forms of epilepsies, both acquired and genetic, with specific reference to drug-resistant epilepsies, using both neurophysiological (EEG) and advanced imaging (structural and functional) methods. Research results have been published in leading journals in general neurology (Brain, Annals of Neurology, Neurology) and epilepsy (Epilepsia). A topic of clinical and research interest in recent years has involved time-dependent conditions and status epilepticus. A prospective registry for cases of status epilepticus has been established since 2013 in Modena, resulting in numerous scientific publications, and international collaborations. For the identification of molecular biomarkers of neuronal damage, inflammation, and neurodegeneration.
PUBLICATIONS (1st Jan 2026)
- 308 publications (PubMed) in peer-reviewed, journals
- 16 book chapters
Bibliometric data
− Google Scholar: 11509 citations; h-Index 57; i10-Index 195;
− Scopus: 373 documents; 8913 citations, 50 h-Index; 44% of which as first/last/corresponding author.
PARTICIPATIONS AND/OR LEADERSHIP OF NATIONAL AND INTERNATIONAL RESEARCH GROUPS AND SCIENTIFIC COLLABORATIONS
2024- Responsibility and coordination of a national research network on post-stroke Epilepsy involving the following centers: Udine, Ancona, Acquila, Ravenna, Trieste. The aims of this network is to establish risk factors for post-stroke seizures, develop new predictive scores, and evaluate possible treatments to prevent post-stroke epilepsy. Publication: Meletti et al., Epilepsia 2024.
2022- Collaborator of EBRAINS-AISBL, the unique European research infrastructure for brain research included by the EU in the ESFRI roadmap with structural funding until 2040. The Department of Biomedical, Metabolic and Neuroscience Sciences joined the EBRAINS initiative. Prof. Meletti participates on a specific subproject led by UNIMORE on recordings with 'High-Density-Multi Electrode Arrays' of human tissue from surgical specimens and cellular imaging.
2021- Collaborator in the international research consortium: 'Identifying SUDEP risk: Sleep wakefulness modulation of central autonomic and respiratory networks'. Prof. Meletti represents the Italian PI of the network involving the following entities: (1) University College London, ('UCL'); University of Melbourne, ('UoM'); University of Geneva, ('UoG'); Université De Lorraine, ('UdL'); McGill University, ('McGill'). International PI of the consortium Prof Beathe Diel UCL.
2017- Collaborator and co-founder of the international research consortium: 'Enhancing NeuroImaging and Genetics through MetaAnalysis (ENIGMA)-Epilepsy Working Group'. This is an international consortium involving more than 20 centers involved in advanced imaging and epilepsy genetics research. International coordinators are S. Sisodiya, P. Thompson. Prof. Meletti is local PI at UNIMORE and coordinates subprojects dedicated to advanced imaging in genetic epilepsies.
The consortium has produced several publications in high-impact journals. Publications: Nature Comm 2022; Brain 2022, 2021; Neuropathol Appl Neurobiol 2022; Neuroimage-clinical 2021; Human Brain Mapping 2020; Brain 2018.
2021- Coordination of SINC - LICE inter-society study group for translation of international guidelines and terminology of descriptor terms of electroencephalographic recordings. This project led to the publication of the text: Translation and adaptation to the Italian language of the glossary of terms most commonly used by clinical electroencephalographists and proposal for the format of the EEG report (IFCN Review 2017). Clin Neurophysiol Pract. 2022 Nov 8;7:325-365.
2019- Participation in the national research consortium: 'BRIVAracetam add-on First Italian netwoRk Study'. Network consisting of leading Italian epilepsy centers involved in real-word clinical trials on the use of Brivaracetam. Publications: Drugs Aging 2022; Seizure 2022; Epilepsia 2022; CNS drugs 2021, 2021; Epilepsia 2021.
2018- Participation to the 'Epilepsy Study Group of the Italian Neurological Society'. Publication: Neurol Sci 2020.
2017-2020 Participation in the 'Status Epilepticus' Commission of the Italian League Against Epilepsy. Indications and a treatment guideline were published in 2020. Published in Epilepsy and Behavior 2020.
2015-2017 Scientific direction of a research group for the characterization of super-refractory status epilepticus with the following institutions: Department of Neurology, University Hospital Ostrava, Czech Republic; University of Athens, Medical School, Neuroimmunology Unit, Department of Pathophysiology, Athens, Greece; Department of Neurology, University of Virginia, USA; Division of Neurology, Bambino Gesù Children's Hospital, IRCCS, Rome Italy. This collaboration is evidenced by two publications in scientific journals: Meletti et al., Front Neurol 2017; Meletti et al., Neurology 2015.
2015- Research partnership on status epilepticus between AOU Modena-UNIMORE and Christian Doppler Klinik, Paracelsus Medical University of Salzburg, Austria, Professor E. Trinka and collaborators. Publications: Eur J Neurol 2021; Epilepsia 2021; Eur J Neurol 2021; Epilepsia 2019; Epilepsia 2018; Giovannini et al, Epilepsia 2019; Leitinger et al, Epilepsia 2020; Lattanzi et al, Eur. J. Neurol 2021.
2015- Scientific collaboration with the Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, LondonWC1N 3BG, United Kingdom (Prof Sanjay M. Sisodiya) to study the genetic basis and brain networks involved in the mechanisms of photosensitivity. This collaboration is evidenced by the publication Vaudano et al, Brain 2017; Cioclu et .a, Frontiers Neurol 2021.
2015-2020 Coordinator of the Neuroimaging Commission of the Italian League Against Epilepsy. The work of the group has allowed the development of a network of Italian centers with specific interest in scientific projects in the field of advanced neuroimaging in epilepsy. The following institutes are involved in the collaboration: Department of Child Neurology and Psychiatry,''C. Mondino'' National Neurological Institute, Pavia, Italy; Child Neurology and Psychiatry Unit, Policlinico S. Orsola-Malpighi, Bologna, Italy; Child Neuropsychiatry Unit, IRCCS, Istituto delle Scienze Neurologiche di Bologna Bellaria Hospital, Bologna, Italy; Department of Health Sciences, University of Milano, Milan, Italy; Pediatric Neurology Unit, V. Buzzi Hospital, Milan, Italy; Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
Research activities have resulted in several publications: Front Neurol 2021; Brain Topogr 2021; Front Neurol 2019; Human Brain Mapping 2020, Brain 2017; Neuroimage Clin 2016; Epilepsia 2016; Epilepsy Behav 2015.
2015-2018 Participation in international consortium to evaluate the use of functional MRI to map language in epilepsy surgery. The work of the group, coordinated by CFA Benjamin produced two scientific publications in the journal Human Brain Mapping (2018).
2013-2016 Participation in the regional consortium "Emilia-Romagna Region Project in Neuro-Oncology (PERNO)." The study group has promoted the development of diagnstocio-therapeutic pathways and protocols in the region and led to the publication of numerous publications: World Neurosurgery 2018; J Neuroncol 2018; Neurol Sci 2017; Neurooncol pract 2014; J Neurooncol 2015; Mol Oncol 2014; Epilepsia 2013; PlosOne 2013; PlosOne 2012.
2013- Scientific collaboration with: the IRCCS of Neurological Sciences, University of Bologna (Prof. F. Bisulli) to study the genetic basis of focal epilepsies and epilepsies with sleep-related seizures. This collaboration is evidenced by three recent publications in scientific journals (Vignatelli et al., Sleep 2015; Ricos at al., Annals of Neurology 2016; Vignatelli et al., Sleep 2017; Licchetta et al., Ann Clin Trasl Neurol 2021).
2012- Participation in the international consortium 'Epilepsy, Brain and Mind' dedicated to the study of neuropsychiatric aspects of epilepsies. Activities of the network have led to the organization of international congresses dedicated to these topics and publications Epilepsy Behav 2015; Epilepsy Behav 2013.
2009- 2015 Scientific collaboration with the Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK (Prof. Louis Lemieux). This collaboration is inherent in the development of EEG and functional MRI co-registration method in epilepsy. Three scientific articles have been published: Vaudano et al, Front Neurol 2013; Ruggieri et al, J Neuroscience Methods 2015; Pugnaghi et al, Brain Topography 2014.
2005- Scientific collaboration with the 'C. Munari' Center for the surgical therapy of epilepsy, Niguarda Hospital, Milan (Dr. Laura Tassi). The collaboration is evidenced by the following scientific publications: Mirandola et al 2021; Mirandola et al, Epilepsia 2017; Meletti et al, Clinical Neurophysiology 2015; Meletti et al, Epileptic Disorders 2014; Meletti et al, Neuropsychologia 2012; Pugnaghi et al, Clinical Neurophysiology 2011; Meletti et al, Epilepsia 2006; Rubboli et al, Brain 2006.
FUNDINGS, GRANT OBTAINED
2023 – Research Unit Leader of the project: The Language Of Dreams: the relationship between sleep mentation, neurophysiology, and neurological disorders. Call for Research PRIN 2022. Research project funded by the Ministry of University and Research. PI Giulio Bernardi - IMT Lucca. Project code: 2022BNE97C. Funding: 317,00 euro. RU Meletti: 87,000 euro.
2023 - Principal Investigator for the project: Cannabidiol effects on sleep structure and slow wave activity in patients with Developmental and Epileptic Encephalopathies. Funded by Jazz pharmaceuticals. Funding: €70,000,00.
2022 – Principal Investigator for the project: Home ultra-long-term EEG monitoring for rare epilepsies and developmental and epileptic encephalopathies. An open-label nonpharmacological interventional prospective study by means of minimally invasive wearable EEG device. PNRR Research Call 2022. Research project funded by the Ministry of Health. Project code: PNRR-MR1-2022-12376491. Funding: €1,000,000.
2021- Research Unit Leader of the project: Effects of nicotinic acetylcholine receptors on inflammation and neuropathology associated with COVID-19. Project funded by the University of Modena and Reggio Emilia. Scientific head prof. M. Zoli. Funding 66,000 euro
2021- Principal Investigator. Winner of the 2021 call for proposals for the acquisition of instrument named 'EllaTM automated immunoassay analyzer'. Project funded by the University of Modena and Reggio Emilia. Funding 30,000 euros.
2020-2023. Principal Investigator of the project: Neurofilaments as biomarkers of disease progression in neurological disorders. Funding of a fixed-term researcher position type A - University of Modena and Reggio Emilia.
2020-2023. Co-investigator. EU project FLAG–ERA JTC 2019: Advanced Morphological Reconstruction of Human Brain Tissue by Multimodal Fusion of Multiscale Optical Imaging Technologies. Principal Investigator prof. J. Mapelli. Funding 115.000 euro
2018 – 2022 Research Unit Leader of the project Status epilepticus: improving quality of therapy and care in the Emilia-Romagna Region. Bando di Ricerca Finalizzata 2016. Research project funded by the Ministry of Health. Scientific head prof. P.Tinuper. Project code: RF-2016-02361365. Funding: 450,000 euro
2016-2018 Scientific Lead for the project: The claustrum in human focal epilepsy. University Research Fund 2016. Project funded by the University of Modena and Reggio Emilia. Funding: 9,000 euros.
2015-2018 Workpackage Principal Investigator of the ‘Progetto di Rete - Ricerca Finalizzata 2013’: Magnetic resonance imaging in drug-refractory temporal lobe epilepsy: standardization of advanced structural and functional protocols at 3T, to identify hippocampal and extra-hippocampal abnormalities. Research project funded by the Ministry of Health. Project code: NET-2013-02355313. Total funding 1,300,000 euros; workpackage funding Prof. Meletti 339,000 euros.
2011-2013 Research Unit Leader of the project: Neurosteroids as determinants of drugs refractoriness in temporal lobe epilepsy. Research project funded by the Ministry of Health. Scientific head Prof. G. Biagini. RF-2011-02350485. Funding: 446,000 euro
2010-2013 Principal Investigator of the project Functional Imaging in Resistant Epilepsy. Development of EEG-fMRI co-registrations: a new non-invasive localization technique for patients with drug-resistant epilepsy. CaRisMo Foundation. Funding: 110.000 euro.
2008-2011 Research Unit Leader of the project: Mechanisms, diagnosis, and treatment of drug-resistant epilepsy. Project funded by the Ministry of Health. Scientific head prof. P.F.Nichelli. Funding: 215,000 euros.
CLINICAL TRIALS
A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy.
Study approval 15/03/2025.
Sponsor: BioHaven pharma.
Recruitment: open
A Phase 2/3 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of BHV-7000 as Adjunctive Therapy in Subjects with Idiopathic Generalized Epilepsy with Generalized Tonic-clonic Seizures, with Open-label Extension.
Study approval 15/05/2025.
Sponsor: BioHaven pharma.
Recruitment: open
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Fixed-Dose, Multicenter Study to Examine the Efficacy and Safety of ZX008 in Subjects with CDKL5 Deficiency Disorder Followed by an Open-Label Extension. Sponsor: Zogenix International Limited.
Study approval 15/06/2024.
Sponsor: UCB pharma.
Recruitment: open
A double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety, and tolerability of intravenous ganaxolone added to standard of care in refractory status epilepticus. RAISEII. Sponsor: Marinus Pharmaceuticals, Inc.
Periictal MRI abnormalities in status epilepticus (PMA-SE) – Prospective, interventional, multicenter study (Modena - Salzburg). Aimed at evaluating the incidence of peri-ictal MRI changes in patients with status epilepticus.
Study approval 01/07/2021.
Sponsor: spontaneous research.
Recruitment: open, duration 3 years.
S100b as a marker of neurological complications in covid19 patients. Multicenter interventional study (Modena - IRCCS Bologna).
Study approval 02/05/2022.
Sponsor: spontaneous research.
Recruitment: closed, duration 2 years.
AL001-3 - Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of AL001 in subjects at risk of or with frontotemporal dementia due to heterozygous mutations in the progranulin gene.
Study approval 07/08/2020.
Sponsor: Alector.
Recruitment: open, duration 2 years.
EP103-BRITOBA - A 12-month noninterventional observational multinational study to evaluate effectiveness, tolerability, and quality of life of Brivaracetam adjunctive therapy in earlier treatment lines in adult patients with history of partial-onset seizures in daily clinical practice.
Study approval 11/10/2020.
Sponsor: UCB Biopharma SRL.
Recruitment: closed, study terminated.
TeleNS-ED "Neurological teleconsultation in the emergency department: an open-label clinical trial”.
Study approval 10/09/2020.
Sponsor: Azienda Ospedaliera-Universitaria di Modena.
Study completed.
Local investigator in the clinical study: SIN-COVID Neurological manifestations during n-CoV-19 infection (NEURO-COVID).
Study approval 04/11/2020.
Promoter: IRCCS IAI Istituto Auxologico Italiano, University of Milano-Bicocca, University of Milan, under the auspices of SIN Italian Society of Neurology.
Open study, closed enrollment.
A noninterventional study of lacosamide and other antiepileptic drugs in the treatment of partial-onset seizures, including a discrete-choice Experiment. VOTE.
Study approval: 18/03/2019
Sponsor: UCB pharma.
Study completed.
Principal Local principal investigator in the clinical study: Does the management of epilepsy in clinical practice reflects the needs expressed by patients? prospective study of patient-physician comparison - epineeds".
Approval Date: 07/25/2017
Promoter: Mario Negri Institute, Milan, Italy.
Study completed.
Prospective, multicenter study on post-traumatic epilepsy in Emilia-Romagna. Identification code PEPIPOSTT (POST- Traumatic epilepsy project).
Approval Date: 05/09/2017
Promoter: ASMN Reggio-Emilia.
Study Completed
SAGE 547-SSE-301 Super-Refractory Status Epilepticus clinical trial. A phase III trial on super-refractory status epilepticus.
Study approval: 10/11/2015
Sponsor: SAGE therapeutics.
Study completed.
A multicenter, prospective, real-life observational study of perampanel as add-on therapy in adult and adolescent patients with focal seizures.
Study approval: 09/02/2016
Sponsor: EISAI.
Study completed.
SP0994 - A multicenter, double-blind, double-dummy, follow up study evaluating the long-term safety of lacosamide (200 to 600mg/day) in comparison with carbamazepine (400 to 1200mg/day), used as monotherapy in patients with partial onset or generalized tonic-clonic seizures (≥16 years) coming from the SP0993 study.
Study approval: 07/02/2012
Sponsor: UCB pharma.
Study completed.
SP0993 – A multicenter, doubleblind, doubledummy, randomized, positive-controlled study comparing the efficacy and safety of lacosamide (200 to 600mg/day) to controlled release carbamazepine (400 to 1200mg/day), used as monotherapy in subjects (≥16 years) newly or recently diagnosed with epilepsy and experiencing partial onset or generalized tonic clonic seizures.
Study approval: 03/06/2011
Sponsor: UCB pharma.
Study completed.
SP0992 - PROMETEO a prospective observational study to asses the treatment effect after the introduction of a different AED in patients with partial epilepsy fulfilling the ILAE 2009 criteria of drug resistant epilepsy.
Study approval: 01/06/2010
Sponsor: UCB pharma.
Study completed.
INVITED SPEAKER, LECTURES AT INTERNATIONAL CONFERENCES AND COURSES
2025. American Epilepsy Society – annual meeting. Atlanta dec. 05-09. Lecture: ultralong-eeg monitoring in drug-resistant focal and generalized epilepsy.
2025. Artificial Intelligence for Neuroscience: from basic research to clinical practice. Milan October 15-17. Lecture: AI in Epilepsy.
2025. International epilepsy congress. Lisbon, portugal september 1 – 4. lecture: Neurofilament and other blood biomarkers in status epilepticus
2025. autoimmune associated epilepsy conference. Barcelona, Spain. june 26-28. lecture: NORSE - Epidemiology, clinical presentation and neurophysiology.
2025. 11th EAN Congress Helsinki, Finland, 21-24 June 2025. lecture: The EEG and seizure semiology.
2025. status epilepticus and symtpomatic seizures (STESS) conference. Goteborg, sweden. april 2 – 4. lecture: Blood Biomarkers in Status Epilepticus
2025. sociedad andaluza de epilepsia, annual congress. Malaga, spain march 27-29. lecture: Diagnosis and Management of Non-convulsive Status Epilepticus. When and How much to treat.
2024. american epilepst society annaual meeting. los angeles 2024, december 3 – 7 . lecture: AI for Analysis of EEG in Critically Ill Patients
2024. 15th european epilepsy congress. rome, 2024 september 7 – 11. lecture: Identification of the epileptogenic zone on MRI by Artificial intelligence.
2024. 10th Congress of the European Academy of Neurology – Helsinki 2024, 29 June - 2 July 2024. Lecture: Evaluating a patient after the first seizure.
2024. European Academy of Neurololgy Regional Teaching Day in Szeged, Hungary. June, 24th. EPILEPSY: Therapeutic recommendations for drug-refractory epilepsy.
2024. 9th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures. “Artificial Intelligence in Status Epilepticus”. April 26 – 28, 2024 London, UK April 8 - 10, 2024 Imperial College London, UK
2023. epilepsy dialogs, London. Navigate the challenges in managing patients with LGS: diagnosis, seizures and non-seizure-related outcomes. 10-11 Novembre London,
2022. Spanish epilepsy society annual meeting. The neuroimaging of Status Epilepticus. barcelona April 27.
2022. ‘gray matters in status epilepticus’. 14th European Epilepsy Congress, 9-13 July 2022 in Geneva, Switzerland
2020. 17th pan arab union of neurological societies. invited lecture: Approach to a patient with drug resistant epilepsy. cairo, egypt; 13-15 febrauary 2020.
2019. 4th International Epilepsy Symposium Seizures, Cognition and Behavior. invited lecture: temporal lobe epilepsy and emotion. bielefeld germany, sePtembeR 6-7 2019.
2019. 7th mediterranean neuroscience conference. invited lecture: the role of the claustrum in human epilepsy. 23-27 june, marrakech, marocco.
2019. 6th international course on drug resistant epilepsies. Invited lecture: connectivity and drug-resistance. Tagliacozzo May 5-11 2019.
2018. 5th international course on drug resistant epilepsies. invited lecture: unclassified type seizures in adults: tools and methods for understanding the network. rome september 20th 2018.
2018. 19th international symposium on severe infantile epilepsies: old and new treatments. invited lecture: epileptic networks and cognitive decline. rome september 20-22 2018.
2018. 13th European congress in epileptology. Invited lecture: the social brain – its development, neurology and epilepsy. Vienna 26-30 august 2018.
2018. Adriatic neurologic forum 2018. Invited lecture: focal seizures in adults. Vidoesession. Monopoli, puglia, may 23-27 2018.
2018. 4th international congress on epilepsy brain and mind. invited lecture: emotion reconition of faces and prosody. do they link to each other? brno, czech republic, may 2-5 2018.
2017. Spanish Neurological Society. invited lecture: La neuroimagen como herramienta diagnóstica en el Status Epiléptico. valencia, 20 novembre 2017
2017. workshop: updates on epilepsy, rome, 10-12 may 2017. invited lecture: understanding epileptic networks.
2017. 4th International ILAE Residential Course on Drug Resistant Epilepsies. rome-tagliacozzo 7-13 may 2017. invited lecture: connectivity and drug-resistance.
2017. 6th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures. SALZBURG. 6-8 APRIL 2017. invited LECTURE: NEUROIMAGING OF STATUS EPILEPTICUS.
2016. First European Glut1 Disease Conference. Milan, Italy 7-8 October 2016. invited lecture: Brain Correlates Of Spike And Waves Discharges In Glut1DS.
2016. 12th European Congress on Epileptology, Prague, Czech Republic, 11-15 September 2016. invited lecture: social cognition in epilepsy patients.
2016. Brain exploration and Epilepsy Surgery. San Servolo, venice 10-22 July 2016. International School of Neurological Sciences of Venice. invited Lecture: imaging in the presurgical workup: fMRI.
2015. 1st workshop on epilepsy and sleep in children. march 5 – 7th bologna. session chair: tracing the development of neural networks.
2014. 11th European Epilepsy Congress, Stockholm, Sweden June 2014. invited Lecture: Social Cognition in temporal lobe epilepsy.
2014. Epilepsy, Brain & Mind 2014. brno, czech republic, April 2014. invited lecture: Recognition of emotion in epilepsy.
2014. 20th Ecole Pratique Bancaud-Talairach. Prignac, france may 2014. invited lecture: Manifestations émotionnelles et dysautonomiques induites par la stimulation limbique.
2013. Brain connectivity in Epilepsy and Sleep, November 11, modena 2013. lecture: questions, limitations, and future perspectives.
2012. 2nd Epilepsy, Brain & Mind Congress. Prague, Czech Republic march 2012. invited lecture: Emotion recognition in epilepsy.
2012. 10th European Epilepsy Congress. LOndon, uk, September 30th - October 4th. invited lecture: Recognition of emotions in temporal lobe epilepsy.
2010. 1st Epilepsy, Brain & Mind Congress, prague, czech republic, March 18 – 20th. invited lecture: Emotion recognition in temporal lobe epilepsy.
2010. 2nd meeting of the Federation of the European societies of Neuropsychology, Amsterdam, Nederland 2010, September. invited lecture: emotion recognition in temporal lobe epilepsy.
2008. 8th European Epilepsy Congress. Berlin, Germany 2008, September. invited lecture: Semiology and cognitive assessment of seizures with intense emotional component.
2005. 26th International Epilepsy Congress. Paris, France 2005, 28th August – 1st September. invited lecture: Recognition Of Facial Expression Of Emotions In MTLE.
2004. Understanding Emotions: Insights into Emotion, Communication and the Brain. Freudental, Germany, September 23 – 26, 2004. invited lecture: Emotional processing in temporal lobe epilepsy
2004. 6th european congress on epileptology. vienna 31 may- 3 june 2004. invited lecture: Disruption of Neural networks subserving fear recognition in TLE.
2000. 4nd european congress on epileptology. 6-12 october, florence. invited lecture: Dysruption of “motor execution” responsible for simultaneous ictal speech and motor arrest related to paracentral glioma.
TEACHING AND SUPERVISION ACTIVITIES
Lecturer in master’s and bachelor’s degree programs
2018-2025 Malattie del sistema Nervoso – CdL Medicina. V° anno, I° ciclo semestrale. Ore: 123. 9 CFU.
2008-2017 Malattie del sistema Nervoso – CdL Medicina. V° anno, I° ciclo semestrale. Ore: 62. 8 CFU
2009-2023 Neurologia – CdL Ortodonzia e Protesi Dentaria. III° anno, II° ciclo semestrale. Ore: 20. 2 CFU
2019-20 Medicina personalizzata in Neurologia. CdL Biotecnologie Mediche. Ore: 16. 2 CFU.
2008-13 Neuroscienze – CdL Logopedia. III° anno, I° ciclo semestrale. Ore: 20. 2 CFU.
PhD Courses
2015 - Lecturer in "Clinical Neurophysiology" as part of the Doctoral Program in Neuroscience.
Master
2022- Level II university master's degree "neurophysiology in the emergency department" - University of Florence. Lecture: the non-convulsive status epilepticus.
2022- Level II inter-university master's degree in "epileptology" - University of Genoa. Lectureship: methods of EEG and advanced imaging.
2023- Inter-university Master's Degree Level II in "clinical neurophysiology" - University of Bologna, University of Messina, University Federico II, University of Milan, University la Sapienza. Lecturer: Electro-encephalography 2 module.
Medical specialty schools
Since November 2018 to 2024, Prof. Meletti has been the director of the School of Neurology.
Since 2019 He is also a member of the Board of the School of Geriatrics.
Lecturer in the following schools:
2008- School of Neurology
2011- School of Emergency medicine
2012- School of Internal medicine
2015- School of Orthopedic
2015- School of Geriatrics
2016- School of Legal medicine
2016- School of Ophthalmology
2012-2015 School of Rheumatology
2012-2015 School of Pharmacology
Thesis supervisor for undergraduate medical students
2024/25: Amit Oz, Giulia Menghi, Sassatelli Giorgia, Jeffe Laurein Donstop.
2023/24: Dondi Francesco, Cavicchi Gilda.
2022/23: Ballabeni Alice, Bertolini Pietro, Burani Margherita, Gherardi Simone, Menabue Manuel, Ronzoni Matteo.
2021/22: Avanzini Irene; Casari Federica; Ceccardi Gloria; Donofrio Michele; Marcheselli Simone.
2020/21: VanDerMost Laura; Mucci Simone; Scolastico Simona; Righi Veronica; Casolari Giulia; Gazzani Giulio; Fontanesi Davide.
2019/20: Saidi Sabrine; Fogliani Marco; Smolig Krystof; De Napoli Giulia; Bertolini Camilla; Miani Alice; Piras Chiara; Manni Chiara; Faso Chiara.
2018/19: Pagnotta Stefania; Parmeggiani Loris; Ripa Claudio; Baroni Francesca; Argenziano Giacomo; Balbarini andrea; Anceschi Pietro.
2017/18: Mengoli M. Chiara; Simoni Lucia; Bonucchi Gregorio; Pasini Francesco; Borelli alessandro; Baricca Beatrix.
2016/17. Rollo Silvia; Orlandi Niccolò; Pini Nicole; Nobile giulia.
2015/16: Olivotto Sara.
2014/15: Bricoli Serena.
2010/11: Ruggieri Andrea
2009/10: Pilato Emanuele
Neurology resident thesis supervisor
2022/23: Biagioli Niccolò, Giacobazzi Laura, Argenziano Giacomo
2021/22: Niccolò Orlandi
2020/21: Rossi Jessica; Cristina Cioclu; Iori Erika
2019/20: Mazzoli Marco; Cilolli Ludovico; Camera Valentina;
2018/19: Menozzi Elisa
2014/15: Giovannini Giada; Mirandola Laura
2012/13: Monti Gilulia
2011/12: Pugnaghi Matteo
Superivisor for the following PhD students in Neuroscience
2024/25: Maria Cristica Cioclu. PhD school in Neuroscience, XXXVII° ciclo. Thesis: Genetic and drug-resistant epilepsies: clinical, functional, and therapeutic insights.
2022/23 Marco Mazzoli. PhD school in Neuroscience, XXXVI° ciclo. Thesis: The role of IgM in cerebrospinal fluid in Guillain-Barrè syndrome.
2021/22: Alice Ballerini. PhD school in Neuroscience, XXXV° ciclo. Thesis: Brain Morphometry in Temporal Lobe Epilepsy: cortical and subcortical patterns of atrophy and connectivity.
2021/22: Talami Francesca. PhD school in Neuroscience, XXXIV° ciclo. Thesis: EEG – fMRI coregistration in epilepsy.
2021/22: Melegari Gabriele. PhD school in Neuroscience, XXXIII° ciclo. Thesis: post-surgical delirium in the elderly.
2020/21: Mirandola Laura. PhD school in Neuroscience, XXXII° ciclo. Thesis: Structural and functional MRI alterations in patients with Temporal Lobe Epilepsy eligible for surgery: a study on the contribution of noninvasive neuroimaging techniques to surgical planning.
2019/20: Pietro Avanzini. PhD school in Neuroscience, XXXI° ciclo. Thesis: EEG sensorimotor rhythms and their relevance in normal and pathological conditions.
2016/17: Monti Giulia. PhD school in Neuroscience, XXIX° ciclo. Thesis: The role of cerebrospinal fluid and brain imaging biomarkers in status epilepticus.
2015/16: Ruggieri Andrea. PhD school in Neuroscience, XXVI° ciclo. Thesis: EEG-fMRI contribution in the study of the visual system in epilepsy.
2014/15 Matteo Pugnaghi. PhD school in Neuroscience, XXV° ciclo. Thesis: EEG-fMRI contribution in the study of generalized and focal epilepsy.
Teaching or research positions at qualified foreign universities and research institutes:
2010-2013 Fellowship e collaboration research program with the Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology Queen Square, London. Research program on functional MRI in epilepsy and co-registration of EEG and fMRI.
2015-2016 Teaching assignment to the fourth edition of the two-year second-level master's program entitled “Epilettologia”, International Neurological School – International Venice University e Università degli Studi di Ferrara, Istituto Neurologico “C. Besta”, IRCCS, Milano, Università degli Studi di Torino, Milano, Verona e Firenze.
2016 Lecturer and tutorship for the International Venice University. International residential course: "Brain exploration and epilepsy surgery" - San Servolo, Venice (Italy), 10-22 July, 2016. The Course is also supported by the Neurosurgery Commission, the Diagnostic Commission, the Commission for Asian and Oceanian Affairs and the Commission for African Affairs of the International League Against Epilepsy (ILAE).
External reviewer activities for competitive calls or doctoral courses:
2025 Doctoral thesis reviewer for Università degli Studi Magna Graecia di Catanzaro. Evaluation report for the PhD thesis: “tremor in juvenile myoclonic epilepsy: a neurophysiology and neuroimaging study”.
2023 Doctoral thesis reviewer for Università degli Studi Magna Graecia di Catanzaro. Evaluation report for the PhD thesis: “Circulating micro-RNAs as potential novel diagnostic biomarkers to predict drug resistance in temporal lobe epilepsy: a pilot study”.
2022 Doctoral thesis reviewer for Università degli Studi di Pavia, PhD School in Biomedical Sciences. Evaluation report for the PhD thesis: “Investigating brain structure and function with advanced MRI in health and disease”.
2022 Doctoral thesis reviewer for Università Politecnica delle Marche, PhD School on Human Health. Evaluation report for the PhD thesis: “The impact of Sleep Deprivation in the brain: Endoplasmic Reticulum Stress and Myelin modification”.
2021 External commissioner for the award of the degree of Ph.D. for SCIENZE BIOMEDICHE E NEUROMOTORIE, ciclo 34, Alma Mater Studiorum – Università di Bologna.
2019 Doctoral thesis reviewer for Università degli Studi Magna Graecia di Catanzaro. Evaluation report for the PhD thesis: “The mutual relationship between temporal lobe epilepsy and psychiatric disorders. Psychopathology, personality and neuroanatomical correlates”.
2019 Doctoral thesis reviewer for Università degli Studi Alma Mater Studiorum - Bologna. Evaluation report for the PhD thesis: “Epileptic and developmental encephalopathies: clinical and genetic study of adult patients attending a tertiary epilepsy center”.
2018 Doctoral thesis reviewer for University College London, UK. Evaluation report for the PhD thesis “Automated Classification of Human Epileptic Spikes for the Purpose of Modelling BOLD Changes Using Simultaneous Intracranial EEG-fMRI”.
2017 Reviewer for the Ministry of Space Technology and Space, Israel. Call for Research Program on Medical Bio-Imaging Israel-Quebec Cooperative Scientific Research on "Brain Imaging, In vivo Imaging and Behaving Animals, Optogenetics”.
2017 Doctoral thesis reviewer for Università del Piemonte Orientale. Evaluation report for the PhD thesis in medical sciences and biotechnology: “Neurophysiological study of epileptogenic networks in epilepsy”.
2017 Doctoral thesis reviewer for Università degli Studi Magna Graecia di Catanzaro. Evaluation report for the PhD thesis in biomarcatori delle malattie croniche e complesse: “Development of New Technologies and Analysis of Biosignals for the Research of Biomarkers in Subjects Affected by Parkinson and Epilepsy Diseases”.
2016 Reviewer for Fondation Francaise pour la Reserche sur l’Epilepsie. Progetto: “Diffusion tensor imaging of the thalamocortical network in epilepsy with continuous spikes and waves during sleep”.
2016 External commissioner for the award of the degree of Ph.D. for Facultè de Medecine – Aix – Marseille Univeristè. Comite Scientifique Bureau des Doctorats.
THIRD MISSION ACTIVITES
2023- Development and publication of the WebApp "EEG glossary" dedicated to terminology for the description of EEG tracing in clinical diagnostics. Bilingual Italian-English app. Free of charge. Link: https://eegglossary.org/
2023. February 21, 2023. Modena, Aula Magna Policlinico di Modena Service Center. Spotlight on encephalitis. From anti-NMDAR encephalitis to status epilepticus of unknown origin. The experience of illness as an impetus for solidarity. Dialogue with physicians, patients and caregivers on a rare disease.
2022. Dissemination through Italian League Against Epilepsy web page of 'tips 4 EEG'. Dedicated to electroencephalography for non-expert audiences.
2022. website: UniMoReNeuro - website on neurological research and clinical trial activities in UNIMORE. Project realized thanks to funding from UniMoRe.
2021. MOREMED inter-university student congress April 13-15. Webinar: Electroencephalography biophysical and technical aspects important for clinical applications in the present and future. Scientific popularization seminar on EEG method and its applications.
2021. Nov. 06, 2021. Event: Dementia and mild cognitive disorders: dialogue between patients, family members, clinicians and researchers. Aula Magna Service Center Faculty of Medicine. Information day on dementia aimed at patients, their families, associations and administrations, with discussion on the needs of patients and families.
2020. Board member of the digital channel "braincity". Update website dedicated to the neurological specialist expert in epilepsy with updates on professional issues, literature, rss feed. https://braincity.it
2019. March 11, 2019. Event: world epilepsy day, "Shine a light on epilepsy: get involved." Open-day at the Medical School Service Center; interviews in regional media and press releases in local media.
2019. September 20, 2019. Event: "Modena for Alzheimer's." Sponsored by the City of Modena, UniMoRe, AOU, and AUSL Modena. San Carlo Theater.
2019. November 11, 2019. Event "Focus: epilepsy surgery" live telecast for regional broadcaster TRC.
2018. "in school about epilepsy." Event funded by UniMoRe. The proposed activity is related to the following program: Ministerial Programs for Scientific Dissemination, Orientation, Health Protection. stakeholders: Lay associations of reference for the pathology; First, middle, and high school teachers; Citizens.
2018. February 12, 2018. Event: world epilepsy day, "Don't be afraid of seizures by knowing what to do." Open-day at Baggiovara Civil Hospital; interviews in regional media (TRC) and press releases in local media.
2018. November 14, 2018. Event: New horizons and precision medicine in the treatment of people with epilepsy. At the Service Center Faculty of Medicine. Event organized by the association "Culture & Life" Modena.
2017. May 28, 2017. Event: Therapeutic actualities in epilepsy. "M. Merighi" Medical Circle. Mirandola, Modena.
2016. February 12, 2016. Event: World Epilepsy Day. Open-day at Baggiovara Civil Hospital; interviews in regional media (TRC) and press releases in local media.
2012. Nov. 24, 2012. Event: Paroxysmal epileptic and nonepileptic manifestations in childhood. Family Center of Nazareth, Modena.
