Professore di II fascia
  • Curriculum Vitae
  • Teaching
  • Appointments
  • Research

Born: 4/3/1960, Cremona, Italy
Education: Doctor in Veterinary Medicine (1985), University of Parma
Qualification (1985)


1986: Research Fellow at the Istituto di Industrie Agrarie, University of Pisa, Italy

1997-1990: Research Fellow (EC fellowship) at the Department of Biochemistry and Molecular Biology, University of Leeds, UK

1990-2001: Assistant Professor at the Institute of Human Physiology, University of Parma, Italy

2001-present: Associate professor at the Department of Neuroscience, Section of Physiology, University of Parma, Italy

1992-present: Visiting Professor at the National Institutes of Health, Bethesda, Maryland, USA

Research Area
Molecular Physiology of the olfactory system

Major achievements
1) Identification, purification, sequencing and biochemical characterization of the first mammalian odorant binding protein (OBP) in the olfactory mucosa.
Bignetti E, Cavaggioni A, Pelosi P, Persaud KC, Sorbi RT, Tirindelli R. (1985). Purification and characterization of an odorant binding protein from cow nasal tissue. Eur. J. Biochem. 149: 227-233.

2) ) Identification of Major Urinary Proteins as pheromonal molecules in the mouse.
Cavaggioni A, Findlay JBC, Tirindelli R (1990) Ligand binding characteristics of homologous rat and mouse urinary protein and pyrazine binding protein of calf. Comp. Biochem. Physiol. 96A: 513-520.

3) Identification and cloning of molecules mediating the pheromone signalling in vomeronasal neurons.
Wu Y, Tirindelli R, Ryba NJP (1996). Evidence for differences in the chemosensory signal transduction pathways of olfactory and vomeronasal neurones. Biochem. Biophys. Res. Commun. 220:900-904
Ryba NJP, Tirindelli R (1995) The novel GTP-binding protein ╬│-subunit is expressed during neurogenesis in the vomeronasal and olfactory epithelium. J. Biol. Chem. 270: 6757-6767

4) Cloning and characterization of the second class of pheromone receptors, V2Rs, in the vomeronasal ogan
Ryba NJP and Tirindelli R (1997) A new multigene family of putative pheromone receptors in mammals. Neuron, 19, 371-379.
Martini, S., Silvotti, L., Shirazi, A., Ryba, N.J.P. and Tirindelli, R. (2001) Co- expression of putative pheromone receptors in the sensory neurons of the vomeronasal organ. J. Neurosci. 21, 843-848 .
Silvotti L, Cavalca E, Gatti R, Percudani R, Tirindelli R (2011) A recent class of chemosensrory neurons developed in mouse and rat. PLoS ONE, 6(9):e24462

5) Identification and functional characterization of a new class of sensory cells (microvillous cells) in the olfactory epithelium.
Elsaesser R, Montani G, Tirindelli R, Paysan J. Phosphatidyl-inositide signaling proteins in a novel class of sensory cells in the mammalian olfactory epithelium.(2005) European Journal of Neuroscience, 21, 2692-700
Montani G, Tonelli S, Elsaesser R, Paysan J, Tirindelli R. (2006). Neuropeptide Y in the olfactory microvillar cells. European Journal of Neuroscience, 24, 20-24

1) Collaboration with Prof. A. Bigiani and A. Menini on: Electrophysiological and immunohistochemical characterization of voltage dependent and Ca activated chloride channels in vomeronasal and olfactory neurons.
Fieni F, Ghiaroni V, Tirindelli R, Pietra P, and Bigiani A (2003) Apical and basal neurons isolated from the mouse vomeronasal organ differ for voltage-dependent currents. J. Physiol. 522.2, 425-436.
Sagheddu C, Boccaccio A, Dibattista M, Montani G, Tirindelli R, Menini A (2010) Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells. J. Physiol. 588, 4189-204.

2) Collaboration with Prof. Castiello on :Effects of odorants on motor action and sexual choice in humans.
Tubaldi F, Ansuini C, Tirindelli R, Castiello U. (2008). The grasping side of odours. PLoS One. Mar 19;3(3):e1795.
Parma, V., R. Tirindelli, et al. (2012). "Subliminally perceived odours modulate female intrasexual competition: an eye movement study." PLoS One 7(2): e30645.

Invitations to conferences, workshops and seminars
-International Symposium: Brain, Nose and Pituitary, Metropolitan Institute of Neuroscience. Tokyo, Japan Dec. 6-8, 2000.
-Cold Spring Harbour Laboratory, New York, USA. Banbury Center. "Molecular Biology of Chemosensory Receptors: the First Decade", March11-14, 2001.
-National Institutes of Health (Bethesda) June, 11, 2001
-Venice, International School for Chemosensory Research, February 18-20, 2002.
-Roma, Meeting of Medical Sexuology, novembre,8-9, 2002
-University of Hoenheim (Stuttgart), June 28th, 2002
-Reisensburg (Germany) April 1-4, 2003. Symposium on Chemosensory Transduction
-University of Darmstadt (Germany) June,2, 2005
-University of Zurich, November, 22, 2007
- European Chemosensory Research Organization. ECRO 2008, Portorose, Slovenia, 2008
-Master Ferrero, Alba, CN, 24 aprile 2009
- European Chemosensory Research Organization XXI ECRO Congress Manchester, UK, Sept. 7-10, 2011.

Other information
-Reviewer of international Journals (J. Neurosci., Eur.J. Neurosci., Eur. J. Biochem., Prooceeding of the Royal Society, Chemical Senses, J.Neurochemistry) and international funding applications ( National Science Foundation, Swiss National Science Foundation, Israel Science foundation, National Institutes of Health)
-Member of the European Chemosensory Research Organization (ECRO)
-National Coordinator of funded National Research Projects: MURST (2001, 2006), CNR (2001), CIB(2002), FIRB (2001).

Anno accademico di erogazione: 2020/2021

Anno accademico di erogazione: 2019/2020

Anno accademico di erogazione: 2018/2019

Anno accademico di erogazione: 2017/2018

Anno accademico di erogazione: 2016/2017

Anno accademico di erogazione: 2015/2016

Anno accademico di erogazione: 2014/2015

Anno accademico di erogazione: 2013/2014


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