Fixed-term researcher
Organizational affiliation: Department of Medicine and Surgery
Neuroscience Unit
SSD: Physics for Life Sciences, Environment, and Cultural Heritage (PHYS-06/A)

Curriculum Vitae

Marialaura Marchetti was born in 1987 in Reggio Emilia, Italy. In 2011 she obtained the MSc with honors in Molecular Biology at the Department of Biochemistry and Molecular Biology of the University of Parma (Parma, Italy). In 2015 she obtained the Doctorate in Biochemistry and Molecular Biology at the University of Parma with a dissertation entitled "Biochemical characterization of human serine racemase: substrates, inhibitors and allosteric effectors". From 2015 to 2017, she actively took part as a Post-Doc (University of Parma) in a Telethon-granted project aimed at the development of an enzymatic uricolytic therapy for the treatment of hypoxanthine-guanine phosphoribosyltransferase deficiency; she contributed to the kinetic characterization of the candidate enzymes and their modification by PEGylation for stability improvement, and to the set-up of an enzymatic biosensor for the evaluation of S-allantoin levels in biological samples. From 2017, as a Post-Doc at the Universities of Parma and Torino (Torino, Italy), she has been involved in the study of bacterial proteins as putative targets for the development of new antimicrobials, with a particular focus on cysteine biosynthetic enzymes and iron-acquisition machineries. From 2021, she is Assistant Professor in Applied Physics at the Department of Medicine and Surgery of the University of Parma.

Teachings

Research

Research areas

- characterization of the interaction between the host's hemoglobin and hemophores from Gram-positive bacteria, able to scavenge heme as an iron supply to sustain growth and infection settlement. These proteins are known pathogens’ virulence factors (e.g. Staphylococcus aureus). 

- characterization of bacterial cysteine synthase complex and the individual enzymes composing it, absent in humans and mammals, responsible for cysteine biosynthesis, whose homeostasis regulates the bacterial cell redox state; test of new antimicrobial adjuvants.

Publications

Public Engagement Initiatives

  • Gli antibiotici: farmaci buoni o cattivi?

    Iniziativa di divulgazione che mediante dimostrazioni, quiz e giochi mira a condurre i visitatori alla scoperta di cosa si intende per antibiotico-resistenza, perché si sviluppa e cosa si può fare per rallentarne la diffusione.

  • L’antibiotico resistenza: cos’è e perché non dobbiamo sottovalutarla

    Evento divulgativo sull'antibiotico-resistenza, sul perché si sviluppa e cosa si può fare per rallentarne la diffusione.

  • Aperitivi della Conoscenza 2023 - Gli antibiotici, una grande risorsa diventata fragile: com’è possibile scoprirne di nuovi?

    Incontro divulgativo

  • ERASE (DEfeat Antimicrobial Resistance through Iron StArvation in Staphylococcus aurEus)

    Cartone animato divulgativo sul tema della resistenza agli antibiotici e sulla ricerca di strategie alternative per combatterla, come bloccare l'acquisizione del ferro.

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