Prof.ssa

MARCHETTI Marialaura

Ricercatore a tempo determinato
Settore scientifico disciplinare
Fisica per le scienze della vita, l'ambiente e i beni culturali
  • Curriculum Vitae
  • Office hour
  • Teaching
  • Appointments
  • Research

Marialaura Marchetti was born in 1987 in Reggio Emilia, Italy. In 2011 she obtained the MSc with honors in Molecular Biology at the Department of Biochemistry and Molecular Biology of the University of Parma (Parma, Italy). In 2015 she obtained the Doctorate in Biochemistry and Molecular Biology at the University of Parma with a dissertation entitled "Biochemical characterization of human serine racemase: substrates, inhibitors and allosteric effectors". From 2015 to 2017, she actively took part as a Post-Doc (University of Parma) in a Telethon-granted project aimed at the development of an enzymatic uricolytic therapy for the treatment of hypoxanthine-guanine phosphoribosyltransferase deficiency; she contributed to the kinetic characterization of the candidate enzymes and their modification by PEGylation for stability improvement, and to the set-up of an enzymatic biosensor for the evaluation of S-allantoin levels in biological samples. From 2017, as a Post-Doc at the Universities of Parma and Torino (Torino, Italy), she has been involved in the study of bacterial proteins as putative targets for the development of new antimicrobials, with a particular focus on cysteine biosynthetic enzymes and iron-acquisition machineries. From 2021, she is Assistant Professor in Applied Physics at the Department of Medicine and Surgery of the University of Parma.

By appointment

Anno accademico di erogazione: 2025/2026

Anno accademico di erogazione: 2024/2025

Anno accademico di erogazione: 2023/2024

Anno accademico di erogazione: 2022/2023

Anno accademico di erogazione: 2021/2022

Professor/Teacher

Lines of research

- characterization of the interaction between the host's hemoglobin and hemophores from Gram-positive bacteria, able to scavenge heme as an iron supply to sustain growth and infection settlement. These proteins are known pathogens’ virulence factors (e.g. Staphylococcus aureus). - characterization of bacterial cysteine synthase complex and the individual enzymes composing it, absent in humans and mammals, responsible for cysteine biosynthesis, whose homeostasis regulates the bacterial cell redox state; test of new antimicrobial adjuvants.

Publications

Orcid

0000-0002-4615-6786

Contacts

Office location

Laboratorio di Biofisica e Fisica Medica, Via Volturno 39, 43125 Parma

Laboratori di Biochimica e Biologia Molecolare, Parco Area delle Scienze 23/A, 43124 Parma

Tel. 0521 904932